Phenotypes associated with this allele

• Allele Symbol: Atg101^em1Nmz
• Allele Name: endonuclease-mediated mutation 1, Noboru Mizushima
• Allele ID: MGI:6508992
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Atg101^em1Nmz/Atg101^em1Nmz	involves: C57BL/6JJcl	MGI:6509965

Genotype
MGI:6509965

hm1

• Allelic Composition: Atg101^em1Nmz/Atg101^em1Nmz
• Genetic Background: involves: C57BL/6JJcl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:300057 )

• homozygotes die around E17.5, with no live mice found at E18.5 or P0.5

growth/size/body

decreased fetal size ( J:300057 )

• slightly smaller than heterozygotes at E17.5

prenatal growth retardation ( J:300057 )

• slightly smaller than heterozygotes at E13.5 and E17.5

respiratory system

abnormal alveolar lamellar body morphology ( J:300057 )

• maturation of lamellar bodies in type II pneumocytes is impaired, as shown by the presence of small and lipid-less lamellar bodies at E17.5

small alveolar lamellar bodies ( J:300057 )

• at E17.5, lamellar bodies labeled with surfactant protein-C (SPC) are smaller than those in heterozygous control mice

small lung ( J:300057 )

• small lung size at E17.0

homeostasis/metabolism

abnormal lipid homeostasis ( J:300057 )

• analysis of lipid content in whole-lung homogenates from E17.0 embryos revealed normal levels of phospholipids (phosphatidyl-choline (DPPC), phosphatidylethanolamine, phosphatidyl-glycerol and phosphatidylinositol), suggesting that delivery of phospholipids from the ER to lamellar bodies, but not synthesis, is impaired