Phenotypes associated with this allele

• Allele Symbol: Fundc2^tm1Qim
• Allele Name: targeted mutation 1, Qi Ma
• Allele ID: MGI:6509183
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fundc2^tm1Qim/Fundc2^tm1Qim	involves: C57BL/6	MGI:6509186

Genotype
MGI:6509186

hm1

• Allelic Composition: Fundc2^tm1Qim/Fundc2^tm1Qim
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

increased apoptosis ( J:301633 )

• increased hypoxia-induced apoptosis in platelets

homeostasis/metabolism

decreased susceptibility to induced thrombosis ( J:301680 )

• longer time to first occlusion in FeCl3-induced carotid artery thrombosis experiments

hematopoietic system

hematopoietic system phenotype ( J:301633 )

N • normal levels of hematopoietic cells, including megakaryocytes, other than platelets under chronic hypoxic conditions

thrombocytopenia ( J:301633 )

• under chronic hypoxia for 5 days

• reduced half-life of thrombocytes in hypoxic conditions owing to increased apoptosis

• normal platelet levels restored after hypoxia experiments when under normoxic conditions for 7 days

immune system

immune system phenotype ( J:301633 )

N • normal spleen morphology