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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fundc2tm1Qim
targeted mutation 1, Qi Ma
MGI:6509183
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Fundc2tm1Qim/Fundc2tm1Qim involves: C57BL/6 MGI:6509186


Genotype
MGI:6509186
hm1
Allelic
Composition		 Fundc2tm1Qim/Fundc2tm1Qim
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fundc2tm1Qim mutation (0 available); any Fundc2 mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
increased apoptosis ( J:301633 )
• increased hypoxia-induced apoptosis in platelets

homeostasis/metabolism
decreased susceptibility to induced thrombosis ( J:301680 )
• longer time to first occlusion in FeCl3-induced carotid artery thrombosis experiments

hematopoietic system
hematopoietic system phenotype ( J:301633 )
N
• normal levels of hematopoietic cells, including megakaryocytes, other than platelets under chronic hypoxic conditions
thrombocytopenia ( J:301633 )
• under chronic hypoxia for 5 days
• reduced half-life of thrombocytes in hypoxic conditions owing to increased apoptosis
• normal platelet levels restored after hypoxia experiments when under normoxic conditions for 7 days

immune system
immune system phenotype ( J:301633 )
N
• normal spleen morphology




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/03/2024
MGI 6.24 		The Jackson Laboratory