Phenotypes associated with this allele

• Allele Symbol: Exoc3^{tm2c(EUCOMM)Hmgu}
• Allele Name: targeted mutation 2c, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:6509449
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Exoc3^tm2c(EUCOMM)Hmgu/Exoc3^tm2c(EUCOMM)Hmgu Tg(Pf4-icre)Q3Rsko/0	involves: C57BL/6 * C57BL/6N	MGI:6509466

Genotype
MGI:6509466

cn1

• Allelic Composition: Exoc3^{tm2c(EUCOMM)Hmgu}/Exoc3^{tm2c(EUCOMM)Hmgu}; Tg(Pf4-icre)Q3Rsko/0
• Genetic Background: involves: C57BL/6 * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal platelet physiology ( J:302300 )

• platelets treated with a glycoprotein VI (GPVI)-selective agonist, collagen-related peptide, show defects in aggregation, integrin activation, alpha-granule, dense granule, and lysosomal granule secretion, and attenuated calcium responses

• platelets show an increase in dense granule secretion and integrin activation after protease-activated receptor 4 activation, but calcium responses are unaltered

decreased platelet dense granule secretion ( J:302300 )

• mice show a defect in GPVI-stimulated platelet dense granule secretion

increased platelet dense granule secretion ( J:302300 )

• platelets show an increase in dense granule secretion after protease-activated receptor 4 activation

decreased platelet aggregation ( J:302300 )

• platelet responses to GPVI stimulation show defects in platelet aggregation

• however, no difference in protease-activated receptor 4-activating peptide (PAR4-AP)-induced platelet aggregation is seen

abnormal thrombosis ( J:302300 )

• whole blood thrombus formation over collagen is reduced

increased susceptibility to induced thrombosis ( J:302300 )

• in a ferric chloride injury model of the carotid artery, mice show accelerated arterial thrombosis

decreased bleeding time ( J:302300 )

• mice exhibit lower bleed time levels with tail tip excision, indicating improved hemostatic function

hematopoietic system

increased mean platelet volume ( J:302300 )

• small, but significant, 8.3% increase in mean platelet volume

• however, blood cell counts are unchanged

abnormal platelet physiology ( J:302300 )

• platelets treated with a glycoprotein VI (GPVI)-selective agonist, collagen-related peptide, show defects in aggregation, integrin activation, alpha-granule, dense granule, and lysosomal granule secretion, and attenuated calcium responses

• platelets show an increase in dense granule secretion and integrin activation after protease-activated receptor 4 activation, but calcium responses are unaltered

decreased platelet dense granule secretion ( J:302300 )

• mice show a defect in GPVI-stimulated platelet dense granule secretion

increased platelet dense granule secretion ( J:302300 )

• platelets show an increase in dense granule secretion after protease-activated receptor 4 activation

decreased platelet aggregation ( J:302300 )

• platelet responses to GPVI stimulation show defects in platelet aggregation

• however, no difference in protease-activated receptor 4-activating peptide (PAR4-AP)-induced platelet aggregation is seen

cellular

decreased platelet dense granule secretion ( J:302300 )

• mice show a defect in GPVI-stimulated platelet dense granule secretion

increased platelet dense granule secretion ( J:302300 )

• platelets show an increase in dense granule secretion after protease-activated receptor 4 activation