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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rasa3tm1.1Llp
targeted mutation 1.1, Luanne Peters
MGI:6509614
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Eportm1.1(EGFP/icre)Uk/Epor+
Rasa3tm1.1Llp/Rasa3tm1.1Llp 		involves: 129S1/SvImJ * BALB/cJ * C57BL/6J MGI:6509624
cn2
 		Eportm1.1(EGFP/icre)Uk/Epor+
Rasa3tm1.1Llp/Rasa3tm1.3Llp 		involves: 129S1/SvImJ * BALB/cJ * C57BL/6J MGI:6510263
cn3
 		Rasa3tm1.1Llp/Rasa3tm1.3Llp
Tg(CMV-cre)1Cgn/? 		involves: 129S1/SvImJ * BALB/cJ * C57BL/6J MGI:6510839
cn4
 		Rasa3tm1.1Llp/Rasa3tm1.1Llp
Tg(Vav1-cre)1Cgp/? 		involves: 129S1/SvImJ * C57BL/6J MGI:6510265
cn5
 		Rasa3tm1.1Llp/Rasa3tm1.1Llp
Tg(Mx1-cre)1Cgn/? 		involves: 129S1/SvImJ * C57BL/6J * CBA/J MGI:6510806
cn6
 		Rasa3tm1.1Llp/Rasa3tm1.1Llp
Tg(Tek-cre)1Ywa/? 		involves: 129S1/SvImJ * C57BL/6J * SJL/J MGI:6510800


Genotype
MGI:6509624
cn1
Allelic
Composition		 Eportm1.1(EGFP/icre)Uk/Epor+
Rasa3tm1.1Llp/Rasa3tm1.1Llp
Genetic
Background		 involves: 129S1/SvImJ * BALB/cJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eportm1.1(EGFP/icre)Uk mutation (2 available); any Epor mutation (27 available)
Rasa3tm1.1Llp mutation (0 available); any Rasa3 mutation (62 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:301035 )
N
• although there is efficient deletion of exon 3 in red cell precursors, mice are normal at birth and at 6-8 weeks of age with normal spleen weights, normal blood morphology, and normal blood counts except for a clinically insignificant decrease in platelet number and slight increase in circulating reticulocytes




Genotype
MGI:6510263
cn2
Allelic
Composition		 Eportm1.1(EGFP/icre)Uk/Epor+
Rasa3tm1.1Llp/Rasa3tm1.3Llp
Genetic
Background		 involves: 129S1/SvImJ * BALB/cJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eportm1.1(EGFP/icre)Uk mutation (2 available); any Epor mutation (27 available)
Rasa3tm1.1Llp mutation (0 available); any Rasa3 mutation (62 available)
Rasa3tm1.3Llp mutation (0 available); any Rasa3 mutation (62 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:301035 )
N
• although there is efficient deletion of exon 3 in red cell precursors, mice are normal at birth and at 6-8 weeks of age with normal spleen weights, normal blood morphology, and normal blood counts except for a clinically insignificant decrease in platelet number and slight increase in circulating reticulocytes




Genotype
MGI:6510839
cn3
Allelic
Composition		 Rasa3tm1.1Llp/Rasa3tm1.3Llp
Tg(CMV-cre)1Cgn/?
Genetic
Background		 involves: 129S1/SvImJ * BALB/cJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rasa3tm1.1Llp mutation (0 available); any Rasa3 mutation (62 available)
Rasa3tm1.3Llp mutation (0 available); any Rasa3 mutation (62 available)
Tg(CMV-cre)1Cgn mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, complete penetrance ( J:301035 )
• intercrosses of heterozygotes in the presence of a cre deleter yield no homozygous null animals at birth, showing the homozygous lethality of the null allele




Genotype
MGI:6510265
cn4
Allelic
Composition		 Rasa3tm1.1Llp/Rasa3tm1.1Llp
Tg(Vav1-cre)1Cgp/?
Genetic
Background		 involves: 129S1/SvImJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rasa3tm1.1Llp mutation (0 available); any Rasa3 mutation (62 available)
Tg(Vav1-cre)1Cgp mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system

embryo

hematopoietic system

mortality/aging
embryonic lethality prior to tooth bud stage ( J:301035 )
• all die in utero at E12.5 and E13.5 with severe hemorrhage and diminished fetal liver erythropoiesis




Genotype
MGI:6510806
cn5
Allelic
Composition		 Rasa3tm1.1Llp/Rasa3tm1.1Llp
Tg(Mx1-cre)1Cgn/?
Genetic
Background		 involves: 129S1/SvImJ * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rasa3tm1.1Llp mutation (0 available); any Rasa3 mutation (62 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased spleen weight ( J:301035 )
• resulting from stress erythropoiesis after Poly(I:C) treatment
abnormal erythropoiesis ( J:301035 )
• adults at 8-12 weeks of age were assessed after being injected with 300 ug Poly(I:C) every other day for 5 days and were found to have suppressed basal erythropoiesis with severe anemia, thrombocytopenia, and leukopenia, with very low CD45- erythroid and CD45+ non-erythroid cell counts in bone marrow, but progression between precursor stages is not affected, and stress erythropoiesis is found with markedly increased spleen size, increased red pulp, increased BFU-E and CFU-E, increased erythroblasts, and reticulocytosis
anemia ( J:301035 )
• profound anemia after Poly(I:C) treatment
decreased erythrocyte cell number ( J:301035 )
• after Poly(I:C) treatment
decreased hematocrit ( J:301035 )
• after Poly(I:C) treatment
decreased hemoglobin content ( J:301035 )
• after Poly(I:C) treatment
increased mean corpuscular volume ( J:301035 )
• after Poly(I:C) treatment
increased red blood cell distribution width ( J:301035 )
• after Poly(I:C) treatment
anisocytosis ( J:301035 )
• after Poly(I:C) treatment
poikilocytosis ( J:301035 )
• after Poly(I:C) treatment
thrombocytopenia ( J:301035 )
• after Poly(I:C) treatment
increased mean platelet volume ( J:301035 )
• after Poly(I:C) treatment
decreased leukocyte cell number ( J:301035 )
• after Poly(I:C) treatment
reticulocytosis ( J:301035 )
• after Poly(I:C) treatment
pancytopenia ( J:301035 )
• after Poly(I:C) treatment
increased megakaryocyte-erythroid progenitor cell number ( J:301035 )
• in spleen after Poly(I:C) treatment
hemolysis ( J:301035 )
• indicated by increased LDH and bilirubin after Poly(I:C) treatment
bone marrow failure ( J:301035 )
• after Poly(I:C) treatment

homeostasis/metabolism
increased circulating bilirubin level ( J:301035 )
• after Poly(I:C) treatment

immune system
increased spleen weight ( J:301035 )
• resulting from stress erythropoiesis after Poly(I:C) treatment
decreased leukocyte cell number ( J:301035 )
• after Poly(I:C) treatment
bone marrow failure ( J:301035 )
• after Poly(I:C) treatment

growth/size/body
increased spleen weight ( J:301035 )
• resulting from stress erythropoiesis after Poly(I:C) treatment




Genotype
MGI:6510800
cn6
Allelic
Composition		 Rasa3tm1.1Llp/Rasa3tm1.1Llp
Tg(Tek-cre)1Ywa/?
Genetic
Background		 involves: 129S1/SvImJ * C57BL/6J * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rasa3tm1.1Llp mutation (0 available); any Rasa3 mutation (62 available)
Tg(Tek-cre)1Ywa mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system

mortality/aging
embryonic lethality prior to tooth bud stage ( J:301035 )
• all die in utero at E12.5 and E13.5 with severe hemorrhage and diminished fetal liver erythropoiesis

embryo

hematopoietic system




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory