Phenotypes associated with this allele

• Allele Symbol: Sfrp4^tm1.1Boer
• Allele Name: targeted mutation 1.1, Derek Boerboom
• Allele ID: MGI:6509974
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sfrp4^tm1.1Boer/Sfrp4^tm1.1Boer	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ	MGI:6509984
cx2	Sfrp2^tm1.1Brle/Sfrp2^tm1.1Brle Sfrp4^tm1.1Boer/Sfrp4^tm1.1Boer	involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * BALB/cJ	MGI:6509983

Genotype
MGI:6509984

hm1

• Allelic Composition: Sfrp4^tm1.1Boer/Sfrp4^tm1.1Boer
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:275639 )

N • male mice exhibit normal fertility

N • female mice exhibit normal serum estradiol, progesterone, and follicle stimulating hormone levels; normal cumulus expansion; and no increase in ovarian apoptosis rates

increased mature ovarian follicle number ( J:275639 )

♀ • due to decreased follicular atresia

abnormal ovarian folliculogenesis ( J:275639 )

♀ • female mice exhibit increased cumulus-oocyte complexes and decreased follicular atresia compared with wild-type mice

increased litter size ( J:275639 )

♀ • unlike Sfrp4^tm1.1Blan, female mice exhibit increased litter size producing 1 extra pup per litter

endocrine/exocrine glands

increased mature ovarian follicle number ( J:275639 )

♀ • due to decreased follicular atresia

abnormal ovarian folliculogenesis ( J:275639 )

♀ • female mice exhibit increased cumulus-oocyte complexes and decreased follicular atresia compared with wild-type mice

Genotype
MGI:6509983

cx2

• Allelic Composition: Sfrp2^tm1.1Brle/Sfrp2^tm1.1Brle; Sfrp4^tm1.1Boer/Sfrp4^tm1.1Boer
• Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * BALB/cJ

reproductive system

increased ovulation rate ( J:275639 )

♀ • increased ovulation

increased litter size ( J:275639 )

♀ • female mice exhibit increased litter size