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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Spata31tm1Yangy
targeted mutation 1, Yong Yang
MGI:6510015
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Spata31tm1Yangy/Spata31tm1Yangy
Tg(Ddx4-cre)1Dcas/0 		involves: 129S7/SvEvBrd * FVB MGI:6510016


Genotype
MGI:6510016
cn1
Allelic
Composition		 Spata31tm1Yangy/Spata31tm1Yangy
Tg(Ddx4-cre)1Dcas/0
Genetic
Background		 involves: 129S7/SvEvBrd * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spata31tm1Yangy mutation (0 available); any Spata31 mutation (31 available)
Tg(Ddx4-cre)1Dcas mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
oligozoospermia ( J:301832 )
• at 8 and 12 weeks of age
teratozoospermia ( J:301832 )
• aberrant spermatogenic cells are seen starting at 6 weeks of age
decreased elongated spermatid number ( J:301832 )
• few elongated spermatids are seen at 8 weeks of age
• by 12 weeks of age round spermatids are nearly absent
small testis ( J:301832 )
• testes size gradually decreases with age and by 12 weeks of age testes are significantly smaller compared to wild-type controls
abnormal spermiation ( J:301832 )
• premature release of germ cells from the seminiferous epithelium
male infertility ( J:301832 )
• males are infertile despite displaying normal mating behavior

cellular
oligozoospermia ( J:301832 )
• at 8 and 12 weeks of age
teratozoospermia ( J:301832 )
• aberrant spermatogenic cells are seen starting at 6 weeks of age
decreased elongated spermatid number ( J:301832 )
• few elongated spermatids are seen at 8 weeks of age
• by 12 weeks of age round spermatids are nearly absent

endocrine/exocrine glands
small testis ( J:301832 )
• testes size gradually decreases with age and by 12 weeks of age testes are significantly smaller compared to wild-type controls




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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory