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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Rasa3tm1.3Llp
targeted mutation 1.3, Luanne Peters
MGI:6510244
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Eportm1.1(EGFP/icre)Uk/Epor+
Rasa3tm1.1Llp/Rasa3tm1.3Llp
involves: 129S1/SvImJ * BALB/cJ * C57BL/6J MGI:6510263
cn2
Rasa3tm1.1Llp/Rasa3tm1.3Llp
Tg(CMV-cre)1Cgn/?
involves: 129S1/SvImJ * BALB/cJ * C57BL/6J MGI:6510839


Genotype
MGI:6510263
cn1
Allelic
Composition
Eportm1.1(EGFP/icre)Uk/Epor+
Rasa3tm1.1Llp/Rasa3tm1.3Llp
Genetic
Background
involves: 129S1/SvImJ * BALB/cJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eportm1.1(EGFP/icre)Uk mutation (2 available); any Epor mutation (25 available)
Rasa3tm1.1Llp mutation (0 available); any Rasa3 mutation (62 available)
Rasa3tm1.3Llp mutation (0 available); any Rasa3 mutation (62 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
N
• although there is efficient deletion of exon 3 in red cell precursors, mice are normal at birth and at 6-8 weeks of age with normal spleen weights, normal blood morphology, and normal blood counts except for a clinically insignificant decrease in platelet number and slight increase in circulating reticulocytes




Genotype
MGI:6510839
cn2
Allelic
Composition
Rasa3tm1.1Llp/Rasa3tm1.3Llp
Tg(CMV-cre)1Cgn/?
Genetic
Background
involves: 129S1/SvImJ * BALB/cJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rasa3tm1.1Llp mutation (0 available); any Rasa3 mutation (62 available)
Rasa3tm1.3Llp mutation (0 available); any Rasa3 mutation (62 available)
Tg(CMV-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• intercrosses of heterozygotes in the presence of a cre deleter yield no homozygous null animals at birth, showing the homozygous lethality of the null allele





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last database update
07/05/2024
MGI 6.24
The Jackson Laboratory