Phenotypes associated with this allele

• Allele Symbol: Gm15441^em1Gonz
• Allele Name: endonuclease-mediated mutation 1, Frank Gonzalez
• Allele ID: MGI:6510264
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gm15441^em1Gonz/Gm15441^em1Gonz	C57BL/6-Gm15441^em1Gonz	MGI:6510282

Genotype
MGI:6510282

hm1

• Allelic Composition: Gm15441^em1Gonz/Gm15441^em1Gonz
• Genetic Background: C57BL/6-Gm15441^em1Gonz

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:299830 )

N • normal serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels after 48 h treatment with WY-14643 and after 24 h fasting with or without treatment with WY-14643

N • normal insulin sensitivity

abnormal homeostasis ( J:299830 )

• increased levels of cleaved CASP1 and IL1B in liver, with or without treatment with WY-14643 and after 24 h fasting

• greater decrease of serum glucose levels after 24 h fasting and after 48 h treatment with WY-14643

• more widespread lipid droplet accumulation in liver after after 24 h fasting

• greater rise in serum non-esterified fatty acids (NEFA), serum and liver triglyceride, and liver total cholesterol levels after 24 h fasting

• normal serum total cholesterol level after 24 h fasting

increased lipoprotein lipase activity ( J:299830 )

• increased total lipase activity in liver after 24 fasting

• normal total lipase activity in skeletal muscle after 24 fasting

• normal total lipase activity in inguinal white adipose tissue after regular feeding and after 24 fasting

digestive/alimentary system

digestive/alimentary phenotype ( J:299830 )

N • normal weight loss after 48 h treatment with WY-14643

liver/biliary system

liver/biliary system phenotype ( J:299830 )

N • normal hepatomegaly after 48 h treatment with WY-14643