Phenotypes associated with this allele

• Allele Symbol: n-TRtct5^tm1.1Slac
• Allele Name: targeted mutation 1.1, Susan L Ackerman
• Allele ID: MGI:6510875
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	n-TRtct5^tm1.1Slac/n-TRtct5^tm1.1Slac	C57BL/6J-n-TRtct5^tm1.1Slac	MGI:6511067

Genotype
MGI:6511067

hm1

• Allelic Composition: n-TRtct5^tm1.1Slac/n-TRtct5^tm1.1Slac
• Genetic Background: C57BL/6J-n-TRtct5^tm1.1Slac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal seizure response to pharmacological agent ( J:297745 )

• higher seizure threshold when treated with pentylenetetrazole (PTZ)

abnormal seizure response to electrical stimulation ( J:297745 )

• higher seizure threshold

nervous system

abnormal seizure response to pharmacological agent ( J:297745 )

• higher seizure threshold when treated with pentylenetetrazole (PTZ)

abnormal seizure response to electrical stimulation ( J:297745 )

• higher seizure threshold

abnormal CNS synaptic transmission ( J:297745 )

• significant reduction in excitatory/inhibitory (E/I) ratio in CA1 region hippocampal neurons

• significant paired-pulse ratio (PPR) decrease in CA1 region hippocampal neurons

abnormal miniature excitatory postsynaptic currents ( J:297745 )

• mEPSC frequency increase in CA1 region hippocampal neurons

• normal mEPSC amplitude and kinetics in CA1 region hippocampal neurons

increased miniature inhibitory postsynaptic current frequency ( J:297745 )

• mIPSC frequency increase in CA1 region hippocampal neurons

abnormal paired-pulse inhibition ( J:297745 )

• no paired-pulse depression (PPD) at short interstimulus intervals in CA1 region hippocampal neurons