Phenotypes associated with this allele

• Allele Symbol: Nexn^tm1.1Chen
• Allele Name: targeted mutation 1.1, Ju Chen
• Allele ID: MGI:6510878
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nexn^tm1.1Chen/Nexn^tm1.1Chen	Not Specified	MGI:6514898
ht2	Nexn^tm1.1Chen/Nexn^+	Not Specified	MGI:6511092

Genotype
MGI:6514898

hm1

• Allelic Composition: Nexn^tm1.1Chen/Nexn^tm1.1Chen
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:290931 )

• all mice die before P12

growth/size/body

enlarged heart ( J:290931 )

• severe cardiac enlargement starting from P5

increased heart weight ( J:290931 )

• heart weight to body weight and heart weight to tibial length ratios are increased starting at P5

decreased body weight ( J:290931 )

• mice exhibit decreased body weight starting at 5 days after birth

cardiovascular system

enlarged heart ( J:290931 )

• severe cardiac enlargement starting from P5

increased heart weight ( J:290931 )

• heart weight to body weight and heart weight to tibial length ratios are increased starting at P5

dilated heart left ventricle ( J:290931 )

• severe left ventricle dilation starting from P5 that progresses to thinning of cardiac walls at P10

dilated cardiomyopathy ( J:290931 )

• mice develop severe progressive dilated cardiomyopathy

decreased cardiac muscle contractility ( J:290931 )

• fractional shortening percentage is reduced by 20% at P1

• however, no differences in fractional shortening percentage are seen at E18.5

abnormal heart echocardiography feature ( J:290931 )

• echocardiography shows increased left ventricular diameter and reduced systolic cardiac function, with a decrease in fractional shortening percentage

homeostasis/metabolism

abnormal ventricular thrombosis ( J:290931 )

• collagen positive mural masses are seen in left ventricles from P7 onward, however elastic fibers are absent and fibrin is present in these structures, suggesting they are intracardiac mural thrombi rather than fibroelastosis

muscle

dilated cardiomyopathy ( J:290931 )

• mice develop severe progressive dilated cardiomyopathy

decreased cardiac muscle contractility ( J:290931 )

• fractional shortening percentage is reduced by 20% at P1

• however, no differences in fractional shortening percentage are seen at E18.5

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
dilated cardiomyopathy 1CC		DOID:0110424	OMIM:613122	J:290931

Genotype
MGI:6511092

ht2

• Allelic Composition: Nexn^tm1.1Chen/Nexn⁺
• Genetic Background: Not Specified

cardiovascular system

cardiovascular system phenotype ( J:301807 )

N • hearts show no signs of cardiac disease at 10 months of age and mice show no altered cardiac function or dilated cardiomyopathy