Phenotypes associated with this allele

• Allele Symbol: Apold1^tm1Pfw
• Allele Name: targeted mutation 1, Paul Worley
• Allele ID: MGI:6511000
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Apold1^tm1Pfw/Apold1^tm1Pfw	involves: C57BL/6	MGI:6511747

Genotype
MGI:6511747

hm1

• Allelic Composition: Apold1^tm1Pfw/Apold1^tm1Pfw
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased susceptibility to ischemic brain injury ( J:302897 )

• after 90 min of middle cerebral artery occlusion (MCAO) followed by reperfusion, adult mice exhibit significantly less cerebral edema formation than wild-type controls; however, no differences are observed in infarct size at 24 or 72 hours or in neurological deficit scores at 1.5 or 72 hours after stroke relative to wild-type controls, indicating that acute stroke outcomes are not altered

nervous system

decreased susceptibility to ischemic brain injury ( J:302897 )

• after 90 min of middle cerebral artery occlusion (MCAO) followed by reperfusion, adult mice exhibit significantly less cerebral edema formation than wild-type controls; however, no differences are observed in infarct size at 24 or 72 hours or in neurological deficit scores at 1.5 or 72 hours after stroke relative to wild-type controls, indicating that acute stroke outcomes are not altered