Phenotypes associated with this allele

• Allele Symbol: Kif9^em2Osb
• Allele Name: endonuclease-mediated mutation 2, Research Institute for Microbial Diseases, Osaka University
• Allele ID: MGI:6511743
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kif9^em2Osb/Kif9^em2Osb	involves: 129S2/SvPas * C57BL/6 * C57BL/6NSlc * DBA/2	MGI:6827384

Genotype
MGI:6827384

hm1

• Allelic Composition: Kif9^em2Osb/Kif9^em2Osb
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6NSlc * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

decreased sperm progressive motility ( J:303071 )

♂ • velocity parameters including average path velocity (VAP), straight line velocity (VSL) and curvilinear velocity (VCL) are all significantly reduced, as observed in mice homozygous for the Kif9^em1Osb allele

♂ • however, the % of motile spermatozoa is comparable to than in heterozygous controls

asthenozoospermia ( J:303071 )

♂ • sperm motility is impaired, as observed in mice homozygous for the Kif9^em1Osb allele

reduced male fertility ( J:303071 )

♂ • when mated with wild-type females, males yield a significantly lower number of litters born per plug relative to wild-type males, as observed in mice homozygous for the Kif9^em1Osb allele

cellular

decreased sperm progressive motility ( J:303071 )

♂ • velocity parameters including average path velocity (VAP), straight line velocity (VSL) and curvilinear velocity (VCL) are all significantly reduced, as observed in mice homozygous for the Kif9^em1Osb allele

♂ • however, the % of motile spermatozoa is comparable to than in heterozygous controls

asthenozoospermia ( J:303071 )

♂ • sperm motility is impaired, as observed in mice homozygous for the Kif9^em1Osb allele

nervous system

nervous system phenotype ( J:303071 )

N • mice do NOT exhibit overt hydrocephalus, consistent with mice homozygous for the Kif9^em1Osb allele