Phenotypes associated with this allele

• Allele Symbol: Ttn^em1Kage
• Allele Name: endonuclease-mediated mutation 1, Katja Gehmlich
• Allele ID: MGI:6511815
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ttn^em1Kage/Ttn^em1Kage	B6J.B6N-Ttn^em1Kage	MGI:6511987

Genotype
MGI:6511987

hm1

• Allelic Composition: Ttn^em1Kage/Ttn^em1Kage
• Genetic Background: B6J.B6N-Ttn^em1Kage

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:302920 )

N • normal contractility of unloaded isolated cardiomyocytes

N • normal passive tension in demembranised loaded cardiomyocyte fibres

abnormal heart morphology ( J:302920 )

• increased left ventricular end-systolic and end-diastolic dimension

• normal left ventricular mass and diastolic wall thickness

• normal heart weight normalised to tibial length

• normal left ventricle trabeculation

abnormal myocardium layer morphology ( J:302920 )

• 32% increased cell area for unloaded isolated cardiomyocytes: increased cell width and length

dilated heart left ventricle ( J:302920 )

• increased end-systolic and end-diastolic dimension

• normal mass and diastolic wall thickness

decreased heart left ventricle muscle contractility ( J:302920 )

• reduced fractional shortening of left ventricle

muscle

muscle phenotype ( J:302920 )

N • normal skeletal muscle morphology

abnormal myocardium layer morphology ( J:302920 )

• 32% increased cell area for unloaded isolated cardiomyocytes: increased cell width and length

decreased heart left ventricle muscle contractility ( J:302920 )

• reduced fractional shortening of left ventricle