Phenotypes associated with this allele

• Allele Symbol: Trim35^em1Smoc
• Allele Name: endonuclease-mediated mutation 1, Shanghai Model Organisms Center
• Allele ID: MGI:6512427
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trim35^em1Smoc/Trim35^em1Smoc	C57BL/6J-Trim35^em1Smoc	MGI:6512549

Genotype
MGI:6512549

hm1

• Allelic Composition: Trim35^em1Smoc/Trim35^em1Smoc
• Genetic Background: C57BL/6J-Trim35^em1Smoc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to Orthomyxoviridae infection induced morbidity/mortality ( J:303214 )

• following intranasal infection with Influenza A virus strain A/WSN/33 (H1N1), all mice die on day 8, 9 or 10 post-infection, whereas all infected wild-type controls survive to day 14 (end of observation period)

immune system

decreased macrophage cytokine production ( J:303214 )

• following transfection with poly(I:C) or RNA mimics (5'-pppRNA) or infection with Sendai virus (SeV), peritoneal macrophages show significantly lower mRNA expression of Ifnb1, Tnf, Il6 and Ifit1 (aka Isg56) relative to wild-type macrophages

decreased circulating interferon-beta level ( J:303214 )

• at day 5 post-infection with vesicular stomatitis virus (VSV) by intravenous injection, female mice exhibit significantly lower serum IFN-beta levels than VSV-infected wild-type controls

increased susceptibility to Orthomyxoviridae infection ( J:303214 )

• following intranasal infection with WSN, A/WSN/33 (H1N1), mice exhibit dramatically increased virus titers and more severe bronchopneumonia with prominent viral antigen expression in the lungs at day 3 post-infection, and continue to lose body weight until death, whereas all wild-type controls gain body weight at the late stage of infection

• primary peritoneal macrophages show significantly higher growth titers of WSN (H1N1) virus than macrophages derived from wild-type controls

increased susceptibility to Orthomyxoviridae infection induced morbidity/mortality ( J:303214 )

• following intranasal infection with Influenza A virus strain A/WSN/33 (H1N1), all mice die on day 8, 9 or 10 post-infection, whereas all infected wild-type controls survive to day 14 (end of observation period)

hematopoietic system

decreased macrophage cytokine production ( J:303214 )

• following transfection with poly(I:C) or RNA mimics (5'-pppRNA) or infection with Sendai virus (SeV), peritoneal macrophages show significantly lower mRNA expression of Ifnb1, Tnf, Il6 and Ifit1 (aka Isg56) relative to wild-type macrophages

homeostasis/metabolism

decreased circulating interferon-beta level ( J:303214 )

• at day 5 post-infection with vesicular stomatitis virus (VSV) by intravenous injection, female mice exhibit significantly lower serum IFN-beta levels than VSV-infected wild-type controls