About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Armc12em1Osb
endonuclease-mediated mutation 1, Research Institute for Microbial Diseases, Osaka University
MGI:6512469
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Armc12em1Osb/Armc12em1Osb involves: C57BL/6NJcl * DBA/2NJcl MGI:6513091
cx2
 		Armc12em1Osb/Armc12em1Osb
Tg(CAG-RFP,Acr-EGFP)RBGS002Osb/0 		involves: C57BL/6NJcl * DBA/2NJcl MGI:6513092


Genotype
MGI:6513091
hm1
Allelic
Composition		 Armc12em1Osb/Armc12em1Osb
Genetic
Background		 involves: C57BL/6NJcl * DBA/2NJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Armc12em1Osb mutation (2 available); any Armc12 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:302631 )
N
• female mice exhibit normal fertility
• male mice exhibit normal testes appearance, testis weight, and testis histology
disorganized sperm mitochondrial sheath ( J:302631 )
• disorganized in step 16 spermatids without proper mitochondrial elongation or coiling along the flagellum
decreased sperm progressive motility ( J:302631 )
• with reduced average path velocity, straight line velocity, and curvilinear velocity
decreased fertilization frequency ( J:302631 )
• essentially absent with both cumulus-intact and cumulus-free oocytes
• reduced fertilization with zona pellucida-free oocytes
impaired binding of sperm to zona pellucida ( J:302631 )
• binding is rare
• however, acrosomal reaction occurs in the cases where the sperm does bind the zona pellucida

cellular
disorganized sperm mitochondrial sheath ( J:302631 )
• disorganized in step 16 spermatids without proper mitochondrial elongation or coiling along the flagellum
decreased sperm progressive motility ( J:302631 )
• with reduced average path velocity, straight line velocity, and curvilinear velocity




Genotype
MGI:6513092
cx2
Allelic
Composition		 Armc12em1Osb/Armc12em1Osb
Tg(CAG-RFP,Acr-EGFP)RBGS002Osb/0
Genetic
Background		 involves: C57BL/6NJcl * DBA/2NJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Armc12em1Osb mutation (2 available); any Armc12 mutation (24 available)
Tg(CAG-RFP,Acr-EGFP)RBGS002Osb mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
impaired sperm migration in female genital tract ( J:302631 )
• sperm do not pass through the uterotubual junction

reproductive system
impaired sperm migration in female genital tract ( J:302631 )
• sperm do not pass through the uterotubual junction




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory