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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Armc12em1Osb
endonuclease-mediated mutation 1, Research Institute for Microbial Diseases, Osaka University
MGI:6512469
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Armc12em1Osb/Armc12em1Osb involves: C57BL/6NJcl * DBA/2NJcl MGI:6513091
cx2
 		Armc12em1Osb/Armc12em1Osb
Tg(CAG-RFP,Acr-EGFP)RBGS002Osb/0 		involves: C57BL/6NJcl * DBA/2NJcl MGI:6513092


Genotype
MGI:6513091
hm1
Allelic
Composition		 Armc12em1Osb/Armc12em1Osb
Genetic
Background		 involves: C57BL/6NJcl * DBA/2NJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Armc12em1Osb mutation (2 available); any Armc12 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:302631 )
N
• female mice exhibit normal fertility
• male mice exhibit normal testes appearance, testis weight, and testis histology
disorganized sperm mitochondrial sheath ( J:302631 )
• disorganized in step 16 spermatids without proper mitochondrial elongation or coiling along the flagellum
decreased sperm progressive motility ( J:302631 )
• with reduced average path velocity, straight line velocity, and curvilinear velocity
decreased fertilization frequency ( J:302631 )
• essentially absent with both cumulus-intact and cumulus-free oocytes
• reduced fertilization with zona pellucida-free oocytes
impaired binding of sperm to zona pellucida ( J:302631 )
• binding is rare
• however, acrosomal reaction occurs in the cases where the sperm does bind the zona pellucida

cellular
disorganized sperm mitochondrial sheath ( J:302631 )
• disorganized in step 16 spermatids without proper mitochondrial elongation or coiling along the flagellum
decreased sperm progressive motility ( J:302631 )
• with reduced average path velocity, straight line velocity, and curvilinear velocity




Genotype
MGI:6513092
cx2
Allelic
Composition		 Armc12em1Osb/Armc12em1Osb
Tg(CAG-RFP,Acr-EGFP)RBGS002Osb/0
Genetic
Background		 involves: C57BL/6NJcl * DBA/2NJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Armc12em1Osb mutation (2 available); any Armc12 mutation (24 available)
Tg(CAG-RFP,Acr-EGFP)RBGS002Osb mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
impaired sperm migration in female genital tract ( J:302631 )
• sperm do not pass through the uterotubual junction

reproductive system
impaired sperm migration in female genital tract ( J:302631 )
• sperm do not pass through the uterotubual junction




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory