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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tbc1d21em1Osb
endonuclease-mediated mutation 1, Research Institute for Microbial Diseases, Osaka University
MGI:6513081
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tbc1d21em1Osb/Tbc1d21em1Osb involves: 129S2/SvPas * C57BL/6NSlc MGI:6513095


Genotype
MGI:6513095
hm1
Allelic
Composition		 Tbc1d21em1Osb/Tbc1d21em1Osb
Genetic
Background		 involves: 129S2/SvPas * C57BL/6NSlc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbc1d21em1Osb mutation (2 available); any Tbc1d21 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal sperm mitochondrial sheath morphology ( J:302631 )
• at mitochondrial compaction
• however, mitochondrial sheath does coil around the flagellum
abnormal spermatid morphology ( J:302631 )
• spermatids exhibit abnormal interlocking structure unlike wild-type spermatids

cellular
abnormal sperm mitochondrial sheath morphology ( J:302631 )
• at mitochondrial compaction
• however, mitochondrial sheath does coil around the flagellum
abnormal spermatid morphology ( J:302631 )
• spermatids exhibit abnormal interlocking structure unlike wild-type spermatids




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory