All Phenotypes Rfx7<tm1.1Ggaur> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Rfx7^tm1.1Ggaur/Rfx7^tm1.1Ggaur Rptor^tm1.1Dmsa/Rptor⁺ Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺	involves: 129S/SvEv * C57BL/10 * CBA/Ca	MGI:6513971
cn2	Rfx7^tm1.1Ggaur/Rfx7^tm1.1Ggaur Ncr1^{tm1.1(icre)Viv}/Ncr1⁺	involves: C57BL/6	MGI:6513975
cn3	Rfx7^tm1.1Ggaur/Rfx7^tm1.1Ggaur Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺	involves: C57BL/6 * C57BL/10 * CBA/Ca	MGI:6513967

Allelic Composition	Rfx7^tm1.1Ggaur/Rfx7^tm1.1Ggaur Rptor^tm1.1Dmsa/Rptor⁺ Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
Genetic Background	involves: 129S/SvEv * C57BL/10 * CBA/Ca

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10^{Tg(Vav1-icre)A2Kio} mutation (3 available); any Commd10 mutation (24 available)
Rfx7^tm1.1Ggaur mutation (0 available); any Rfx7 mutation (78 available)
Rptor^tm1.1Dmsa mutation (1 available); any Rptor mutation (117 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal NK cell morphology ( J:282535 )

• reduced cell size and granularity but not as much as in Rfx7^tm1.1Ggaur/Rfx7^tm1.1Ggaur Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ mice

decreased NK cell number ( J:282535 )

• although not as decreased in Rfx7^tm1.1Ggaur/Rfx7^tm1.1Ggaur Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ mice

small spleen ( J:282535 )

hematopoietic system

abnormal NK cell morphology ( J:282535 )

• reduced cell size and granularity but not as much as in Rfx7^tm1.1Ggaur/Rfx7^tm1.1Ggaur Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ mice

decreased NK cell number ( J:282535 )

• although not as decreased in Rfx7^tm1.1Ggaur/Rfx7^tm1.1Ggaur Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ mice

small spleen ( J:282535 )

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased NK cell number ( J:282535 )

• in the spleen, blood, and liver

• mice infected with murine cytomegalovirus exhibit reduced total and Ly49H+ after 1.5 days infection and milder after 3.5 days compared with control mice

abnormal NK cell physiology ( J:282535 )

• decreased survival in vivo and in culture

• treatment with IL2-anti-IL2 complexes partially rescues the ability to reject B2m-deficient splenocytes

• slightly less granzyme A production in uninfected mice

• however, cells exhibit normal cell-mediated immunity when cultured with RMA-S and RMA-H60 target cells

• however, increased IL2 or IL15 amounts restores NK cell survival in culture

increased susceptibility to viral infection ( J:282535 )

• mice infected with murine cytomegalovirus exhibit reduced total and Ly49H+ after 1.5 days infection and milder after 3.5 days with reduced granzyme B production and higher viral loads early after infection in the spleen and lungs compared with control mice

• however, IFNG production from NK cells of cytomegalovirus virus-infected mice

hematopoietic system

decreased NK cell number ( J:282535 )

• in the spleen, blood, and liver

• mice infected with murine cytomegalovirus exhibit reduced total and Ly49H+ after 1.5 days infection and milder after 3.5 days compared with control mice

abnormal NK cell physiology ( J:282535 )

• decreased survival in vivo and in culture

• treatment with IL2-anti-IL2 complexes partially rescues the ability to reject B2m-deficient splenocytes

• slightly less granzyme A production in uninfected mice

• however, cells exhibit normal cell-mediated immunity when cultured with RMA-S and RMA-H60 target cells

• however, increased IL2 or IL15 amounts restores NK cell survival in culture

Allelic Composition	Rfx7^tm1.1Ggaur/Rfx7^tm1.1Ggaur Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
Genetic Background	involves: C57BL/6 * C57BL/10 * CBA/Ca

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal NK cell morphology ( J:282535 )

• reduced cell size and granularity but not as much as in Rfx7^tm1.1Ggaur/Rfx7^tm1.1Ggaur Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ mice

decreased NK cell number ( J:282535 )

• although not as decreased in Rfx7^tm1.1Ggaur/Rfx7^tm1.1Ggaur Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ mice

small spleen ( J:282535 )

hematopoietic system

abnormal NK cell morphology ( J:282535 )

• reduced cell size and granularity but not as much as in Rfx7^tm1.1Ggaur/Rfx7^tm1.1Ggaur Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ mice

decreased NK cell number ( J:282535 )

• although not as decreased in Rfx7^tm1.1Ggaur/Rfx7^tm1.1Ggaur Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ mice

small spleen ( J:282535 )

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