Analysis Tools
immune system
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• approximately 18% increase in the number of secretory granules and a ~15% decrease in granule size
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• decrease in total and secreted levels of histamine and serotonin in IgE-sensitized bone marrow-derived or peritoneum-derived connective-tissue-like mast cells (BMMCs or PCMCs) or IgG-sensitized PCMCs
• however, the ratio of secreted histamine or serotonin to total levels in mast cells is similar indicating that degranulation is not altered
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cardiovascular system
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• IgE- and IgG-stimulated vascular permeability in the skin are significantly decreased compared to wild-type controls
• transfer of arthritic serum fails to induce increased joint vascular leakage unlike in wild-type controls
• transfer of wild-type mast cells into homozygous null mice restores vascular leakage responses
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homeostasis/metabolism
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• in a model of allergic peritonitis, peritoneal lavage fluid contains lower levels of histamine
• however, numbers of mast cells in the peritoneal cavity are similar to controls
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• in a model of allergic peritonitis, peritoneal lavage fluid contains lower levels of serotonin
• however, numbers of mast cells in the peritoneal cavity are similar to controls
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hematopoietic system
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• approximately 18% increase in the number of secretory granules and a ~15% decrease in granule size
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• decrease in total and secreted levels of histamine and serotonin in IgE-sensitized bone marrow-derived or peritoneum-derived connective-tissue-like mast cells (BMMCs or PCMCs) or IgG-sensitized PCMCs
• however, the ratio of secreted histamine or serotonin to total levels in mast cells is similar indicating that degranulation is not altered
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