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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Slc25a28tm1.2Dwrd
targeted mutation 1.2, Diane Ward
MGI:6514336
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Slc25a28tm1.2Dwrd/Slc25a28tm1.2Dwrd involves: 129S6/SvEvTac * C57BL/6NCrl MGI:6514396
cn2
 		Slc25a28tm1.2Dwrd/Slc25a28tm1.2Dwrd
Slc25a37tm1.1Kapl/Slc25a37tm1.1Kapl
Speer6-ps1Tg(Alb-cre)21Mgn/0 		involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCrl * DBA MGI:6514398


Genotype
MGI:6514396
hm1
Allelic
Composition		 Slc25a28tm1.2Dwrd/Slc25a28tm1.2Dwrd
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6NCrl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc25a28tm1.2Dwrd mutation (0 available); any Slc25a28 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
oligozoospermia ( J:300667 )
• reduced sperm count
asthenozoospermia ( J:300667 )
• reduced sperm motility
reduced male fertility ( J:300667 )
• worsening over time; not all animals affected

liver/biliary system
decreased liver iron level ( J:300667 )
• reduced nonheme iron level in liver mitochondria when fed low-iron chow
• reduced nonheme iron level in liver when fed low-iron chow

homeostasis/metabolism
decreased liver iron level ( J:300667 )
• reduced nonheme iron level in liver mitochondria when fed low-iron chow
• reduced nonheme iron level in liver when fed low-iron chow

cellular
oligozoospermia ( J:300667 )
• reduced sperm count
asthenozoospermia ( J:300667 )
• reduced sperm motility
abnormal oxidative phosphorylation ( J:300667 )
• significant reduction in OXPHOS protein levels in liver

hematopoietic system
hematopoietic system phenotype ( J:300667 )
N
• normal hematological parameters
• normal protoporphyrin IX (PPIX) levels in liver when fed aminolevulenic acid (ALA)




Genotype
MGI:6514398
cn2
Allelic
Composition		 Slc25a28tm1.2Dwrd/Slc25a28tm1.2Dwrd
Slc25a37tm1.1Kapl/Slc25a37tm1.1Kapl
Speer6-ps1Tg(Alb-cre)21Mgn/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCrl * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc25a28tm1.2Dwrd mutation (0 available); any Slc25a28 mutation (18 available)
Slc25a37tm1.1Kapl mutation (0 available); any Slc25a37 mutation (9 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
liver/biliary system
impaired liver regeneration ( J:300667 )
• reduced liver cell proliferation 48h after partial hepatectomy

cellular
abnormal oxidative phosphorylation ( J:300667 )
• significant reduction in OXPHOS protein levels in liver

embryo
embryo phenotype ( J:300667 )
N
• mice born at expected Mendelian ratio




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory