Phenotypes associated with this allele

• Allele Symbol: Nlrp9c^em3Okkm
• Allele Name: endonuclease-mediated mutation 3, Tohru Kimura
• Allele ID: MGI:6514382
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Nlrp9a^em3Okkm/Nlrp9a^em3Okkm Nlrp9b^em3Okkm/Nlrp9b^em3Okkm Nlrp9c^em3Okkm/Nlrp9c^em3Okkm	involves: ICR	MGI:6514798

Genotype
MGI:6514798

cx1

• Allelic Composition: Nlrp9a^em3Okkm/Nlrp9a^em3Okkm; Nlrp9b^em3Okkm/Nlrp9b^em3Okkm; Nlrp9c^em3Okkm/Nlrp9c^em3Okkm
• Genetic Background: involves: ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

abnormal blastocyst formation ( J:302234 )

• smaller blastocysts in zygotes that form a blastocyst at E3.5 and E4.5

failure of blastocyst formation ( J:302234 )

• fewer E3.5 mice zygotes develop a blastocyst remaining as morulae or embryos degenerate

failure of zygotic cell division ( J:302234 )

• blocked at the 2-cell stage with asymmetric cell division

embryonic growth retardation ( J:302234 )

• some zygotes do not develop a blastocyst until E4.5

growth/size/body

embryonic growth retardation ( J:302234 )

• some zygotes do not develop a blastocyst until E4.5

mortality/aging

embryonic lethality before implantation, incomplete penetrance ( J:302234 )

• some mice degenerate prior to implantation

reproductive system

long gestation period ( J:302234 )

• slightly

decreased litter size ( J:302234 )

• in female mice crossed with wild-type male mice in addition to more litters with seven or fewer pups compared with wild-type mice

• however, mice have comparable number of deliveries and normal fertilization rates