mortality/aging
• some mice degenerate prior to implantation
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reproductive system
• slightly
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• in female mice crossed with wild-type male mice in addition to more litters with seven or fewer pups compared with wild-type mice
• however, mice have comparable number of deliveries and normal fertilization rates
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embryo
• smaller blastocysts in zygotes that form a blastocyst at E3.5 and E4.5
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• fewer E3.5 mice zygotes develop a blastocyst remaining as morulae or embryos degenerate
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• blocked at the 2-cell stage with asymmetric cell division
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• some zygotes do not develop a blastocyst until E4.5
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growth/size/body
• some zygotes do not develop a blastocyst until E4.5
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