Phenotypes associated with this allele

• Allele Symbol: Eva1a^tm1Nju
• Allele Name: targeted mutation 1, Model Animal Research Center of Nanjing University
• Allele ID: MGI:6514805
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Eva1a^tm1Nju/Eva1a^tm1Nju Tg(Nes-cre)1Kln/0	involves: C57BL/6 * SJL	MGI:6514806

Genotype
MGI:6514806

cn1

• Allelic Composition: Eva1a^tm1Nju/Eva1a^tm1Nju; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

impaired autophagy ( J:301660 )

homeostasis/metabolism

impaired autophagy ( J:301660 )

nervous system

abnormal neurite morphology ( J:301660 )

• short

abnormal neuronal stem cell physiology ( J:301660 )

• impaired neural stem cells differentiation

• however, overexpression of wild-type protein or treatment with methylpyruvate and rapamycin restores differentiation

decreased neuronal stem cell self-renewal ( J:301660 )

• fewer newborn neural stem cells (NSCs) in E12.5 mice without an increase in apoptosis

• NSCs produce smaller-sized neurospheres compared with control cells

• however, overexpression of wild-type protein restores self-renewal