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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		C9em1Sjlg
endonuclease-mediated mutation 1, Shujuan Liang
MGI:6514830
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		C9em1Sjlg/C9em1Sjlg C57BL/6-C9em1Sjlg MGI:6514847
ht2
 		C9em1Sjlg/C9+ C57BL/6-C9em1Sjlg MGI:6514848


Genotype
MGI:6514847
hm1
Allelic
Composition		 C9em1Sjlg/C9em1Sjlg
Genetic
Background		 C57BL/6-C9em1Sjlg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C9em1Sjlg mutation (0 available); any C9 mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
impaired complement classical pathway ( J:301607 )
• deficient hemolysis of sheep or human red blood cells in vitro and in vivo
• however, response to antibody-sensitized sheep or human red blood cells is normal
decreased susceptibility to endotoxin shock ( J:301607 )
• LPS-treated mice exhibit reduced LPS-mediated septic acute shock with increased survival and reduced cytokine (IL1b and membrane attack complex) release compared with wild-type mice




Genotype
MGI:6514848
ht2
Allelic
Composition		 C9em1Sjlg/C9+
Genetic
Background		 C57BL/6-C9em1Sjlg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C9em1Sjlg mutation (0 available); any C9 mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
impaired complement classical pathway ( J:301607 )
• reduced hemolysis of sheep or human red blood cells in vitro




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory