Phenotypes associated with this allele

• Allele Symbol: Ttll8^tm1.2Ics
• Allele Name: targeted mutation 1.2, Mouse Clinical Institute
• Allele ID: MGI:6514903
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Ttll3^tm1.2Ics/Ttll3^tm1.2Ics Ttll8^tm1.2Ics/Ttll8^tm1.2Ics	B6.129S2-Ttll3^tm1.2Ics Ttll8^tm1.2Ics	MGI:6515558

Genotype
MGI:6515558

cx1

• Allelic Composition: Ttll3^tm1.2Ics/Ttll3^tm1.2Ics; Ttll8^tm1.2Ics/Ttll8^tm1.2Ics
• Genetic Background: B6.129S2-Ttll3^tm1.2Ics Ttll8^tm1.2Ics

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

kinked sperm flagellum ( J:300009 )

♂ • flagellar curvature is more than 3 times higher than in wild-type cells

decreased sperm progressive motility ( J:300009 )

♂ • with decreased curvilinear velocity, straight-line velocity, and average path velocity

♂ • asymmetrical flagella beating, premature hyperactivation, and circular swimming paths

asthenozoospermia ( J:300009 )

♂

reduced male fertility ( J:300009 )

♂

decreased fertilization frequency ( J:300009 )

♂ • in vitro fertilization using double null sperm is one fourth of wild-type sperm

nervous system

nervous system phenotype ( J:300009 )

N • mice exhibit normal ependymal cilia morphology and function with no sign of hydrocephaly

renal/urinary system

renal/urinary system phenotype ( J:300009 )

N • mice exhibit normal primary cilia from kidney collecting tubules with no polycystic kidneys

respiratory system

respiratory system phenotype ( J:300009 )

N • mice exhibit normal trachea cilia

cellular

kinked sperm flagellum ( J:300009 )

♂ • flagellar curvature is more than 3 times higher than in wild-type cells

decreased sperm progressive motility ( J:300009 )

♂ • with decreased curvilinear velocity, straight-line velocity, and average path velocity

♂ • asymmetrical flagella beating, premature hyperactivation, and circular swimming paths

asthenozoospermia ( J:300009 )

♂