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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hmgcrem1Bcgen
endonuclease-mediated mutation 1, Biocytogen LLC
MGI:6515596
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Hmgcrem1Bcgen/Hmgcrem1Bcgen Not Specified MGI:6515653
cn2
 		Hmgcrem1Bcgen/Hmgcrem1Bcgen
Usp20em1Gpt/Usp20em1Gpt
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ 		involves: C57BL/6JGpt * DBA MGI:6515654


Genotype
MGI:6515653
hm1
Allelic
Composition		 Hmgcrem1Bcgen/Hmgcrem1Bcgen
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hmgcrem1Bcgen mutation (0 available); any Hmgcr mutation (60 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
homeostasis/metabolism phenotype ( J:299971 )
N
• mice fed a high-fat and high-sucrose diet exhibit normal total cholesterol levels in fasted and refed mice, oxygen consumption, and glucose tolerance
increased circulating triglyceride level ( J:299971 )
• in fasted and refed mice fed a high-fat and high-sucrose diet




Genotype
MGI:6515654
cn2
Allelic
Composition		 Hmgcrem1Bcgen/Hmgcrem1Bcgen
Usp20em1Gpt/Usp20em1Gpt
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic
Background		 involves: C57BL/6JGpt * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hmgcrem1Bcgen mutation (0 available); any Hmgcr mutation (60 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
Usp20em1Gpt mutation (0 available); any Usp20 mutation (49 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
homeostasis/metabolism phenotype ( J:299971 )
N
• mice fed a high-fat and high-sucrose diet exhibit normal total cholesterol levels in fasted and refed mice, oxygen consumption, and glucose tolerance
increased circulating triglyceride level ( J:299971 )
• in fasted and refed mice fed a high-fat and high-sucrose diet




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Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory