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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ssmem1em1Osb
endonuclease-mediated mutation 1, Research Institute for Microbial Diseases, Osaka University
MGI:6515722
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ssmem1em1Osb/Ssmem1em1Osb involves: C57BL/6NJcl * DBA/2NJcl MGI:6515772


Genotype
MGI:6515772
hm1
Allelic
Composition		 Ssmem1em1Osb/Ssmem1em1Osb
Genetic
Background		 involves: C57BL/6NJcl * DBA/2NJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ssmem1em1Osb mutation (2 available); any Ssmem1 mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal sperm head morphology ( J:296963 )
• misshapen nuclei, disorganized mitochondria, and tail entrapment in cytoplasmic droplets
asthenozoospermia ( J:296963 )
• impaired kinematic velocities
abnormal spermiogenesis ( J:296963 )
• delayed migration of the Golgi to the caudal region in all spermatids
• however, sperm exhibit normal acrosome formation

cellular
abnormal sperm head morphology ( J:296963 )
• misshapen nuclei, disorganized mitochondria, and tail entrapment in cytoplasmic droplets
asthenozoospermia ( J:296963 )
• impaired kinematic velocities

endocrine/exocrine glands




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory