Phenotypes associated with this allele

• Allele Symbol: Sardh^em1Tzq
• Allele Name: endonuclease-mediated mutation 1, Zhiqian Tong
• Allele ID: MGI:6515833
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sardh^em1Tzq/Sardh^em1Tzq	Not Specified	MGI:6681878

Genotype
MGI:6681878

hm1

• Allelic Composition: Sardh^em1Tzq/Sardh^em1Tzq
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal hippocampus morphology ( J:285251 )

• reduced sarcosine and formaldehyde levels

reduced NMDA-mediated synaptic currents ( J:285251 )

behavior/neurological

abnormal spatial working memory ( J:285251 )

• impaired in a Morris water maze

• however, treatment with formaldehyde shortens escape latency

growth/size/body

decreased body weight ( J:285251 )

• beginning at 2 weeks of age