Phenotypes associated with this allele

• Allele Symbol: Slc6a7^tm1Veul
• Allele Name: targeted mutation 1, Volker Eulenburg
• Allele ID: MGI:6682116
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc6a7^tm1Veul/Slc6a7^tm1Veul	B6.129P2-Slc6a7^tm1Veul	MGI:6682118

Genotype
MGI:6682118

hm1

• Allelic Composition: Slc6a7^tm1Veul/Slc6a7^tm1Veul
• Genetic Background: B6.129P2-Slc6a7^tm1Veul

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal nervous system physiology ( J:288931 )

• about a 75% reduction in uptake of L-proline in the cortex, hippocampus, striatum, and thalamus

• however, no signs of neurotoxicity are seen

behavior/neurological

behavior/neurological phenotype ( J:288931 )

N • performance on a rotarod is similar to wild-type controls

N • no alteration in immobility time in a tail-suspension test or forced swim test

decreased exploration in new environment ( J:288931 )

• enter and move less in the central area of an open field

• however, no change is observed in a startle-reactivity test suggesting the mice do not display increased anxiety

impaired spatial memory extinction ( J:288931 )

• impaired memory extinction in the Morris water maze when the hidden platform is moved after training

• however, no defect is seen in the initial learning acquisition

abnormal response to novel object ( J:288931 )

• show reduced responsiveness to a novel object with decreases in total distance traveled, number of approaches to the object, and time spent in the central quadrant

decreased locomotor activity ( J:288931 )

• decreased motility in an open field assay

• show reduced mobility in an elevated zero maze but no change in number of entries or time spent in the open area