Phenotypes associated with this allele

• Allele Symbol: Ptpra^{tm1c(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:6682153
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ptpra^tm1c(EUCOMM)Hmgu/Ptpra^tm1c(EUCOMM)Hmgu Sftpc^tm1(cre/ERT2)Blh/Sftpc^+	involves: 129S6/SvEvTac * C57BL/6N	MGI:6690444
cn2	Ptpra^tm1c(EUCOMM)Hmgu/Ptpra^tm1c(EUCOMM)Hmgu Twist2^tm1.1(cre)Dor/Twist2^+	involves: 129X1/SvJ * C57BL/6N	MGI:6690443

Genotype
MGI:6690444

cn1

• Allelic Composition: Ptpra^{tm1c(EUCOMM)Hmgu}/Ptpra^{tm1c(EUCOMM)Hmgu}; Sftpc^{tm1(cre/ERT2)Blh}/Sftpc⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:300194 )

N • bleomycin, tamoxifen-treated mice develop fibrosis and lung collagen content as in control mice

Genotype
MGI:6690443

cn2

• Allelic Composition: Ptpra^{tm1c(EUCOMM)Hmgu}/Ptpra^{tm1c(EUCOMM)Hmgu}; Twist2^{tm1.1(cre)Dor}/Twist2⁺
• Genetic Background: involves: 129X1/SvJ * C57BL/6N

homeostasis/metabolism

decreased susceptibility to injury ( J:300194 )

• bleomycin-treated mice are protected from pulmonary fibrosis