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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Zc3h7aitem1Caox
endonuclease-mediated mutation 1, Xuetao Cao
MGI:6690238
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Zc3h7aitem1Caox/Zc3h7aitem1Caox C57BL/6J-Zc3h7aitem1Caox MGI:7624328


Genotype
MGI:7624328
hm1
Allelic
Composition
Zc3h7aitem1Caox/Zc3h7aitem1Caox
Genetic
Background
C57BL/6J-Zc3h7aitem1Caox
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• all mice die within 4 days after VSV infection by i.v. injection (2 107 pfu per g body weight)

immune system
N
• at 18 h after i.v. injection with the DNA HSV-1 virus (1 107 pfu per g body weight), mice show normal induction of Ifna, Ifnb1, Ifit1 and Il6 mRNA levels in liver, spleen and lung, and no differences in serum IFN-alpha, IFN-beta and IL-6 levels or in lung pathology relative to HSV-1-infected wild-type controls
• isolated peritoneal macrophages show a marked reduction in VSV-dependent induction of phosphorylated IRF3 (p-IRF3), consistent with a reduced antiviral innate response to RNA viruses
• at 18 h after i.v. VSV infection (2 106 pfu per g body weight), mice show significantly lower serum IFN-alpha levels than wild-type controls
• at 24 h after intranasal injection with influenza virus strain A/Puerto Rico/1981 H1N1 (PR8), mice show significantly lower serum IFN-alpha levels than wild-type controls
• at 18 h after i.v. VSV infection (2 106 pfu per g body weight), mice show significantly lower serum IFN-beta levels than wild-type controls
• at 24 h after intranasal injection with influenza virus strain A/Puerto Rico/1981 H1N1 (PR8), mice show significantly lower serum IFN-beta levels than wild-type controls
• at 18 h after i.v. VSV infection (2 106 pfu per g body weight), mice show significantly lower serum IL-6 levels than wild-type controls
• at 24 h after intranasal injection with influenza virus strain A/Puerto Rico/1981 H1N1 (PR8), mice show significantly lower serum IL-6 levels than wild-type controls
• at 18 h after i.v. VSV injection, mice exhibit a significantly lower induction of Ifit1 mRNA levels (an IFN-stimulated gene) in liver, spleen and lung relative to wild-type controls
• at 12h after VSV infection, isolated peritoneal macrophages produce significantly less IFN-alpha than wild-type cells
• at 18 h after i.v. VSV infection, mice show a significantly lower induction of Ifna mRNA levels in liver, spleen and lung relative to wild-type controls
• at 12h after VSV infection, isolated peritoneal macrophages produce significantly less IFN-beta than wild-type cells
• at 18 h after i.v. VSV infection, mice exhibit a significantly lower induction of Ifnb1 mRNA levels in liver, spleen and lung relative to wild-type controls
• at 12h after VSV infection, isolated peritoneal macrophages produce significantly less IL-6 than wild-type cells
• at 18 h after i.v. VSV infection, mice exhibit a significantly lower induction of Il6 mRNA levels in liver, spleen and lung relative to wild-type controls
• at 18 h after i.v. VSV infection, mice show significantly lower serum levels of type I IFNs and IL-6, more severe lung pathology, increased VSV replication, and accelerated VSV-induced lethality relative to VSV-infected wild-type controls
• all mice die within 4 days after VSV infection by i.v. injection (2 107 pfu per g body weight)

homeostasis/metabolism
• at 18 h after i.v. VSV infection (2 106 pfu per g body weight), mice show significantly lower serum IFN-alpha levels than wild-type controls
• at 24 h after intranasal injection with influenza virus strain A/Puerto Rico/1981 H1N1 (PR8), mice show significantly lower serum IFN-alpha levels than wild-type controls
• at 18 h after i.v. VSV infection (2 106 pfu per g body weight), mice show significantly lower serum IFN-beta levels than wild-type controls
• at 24 h after intranasal injection with influenza virus strain A/Puerto Rico/1981 H1N1 (PR8), mice show significantly lower serum IFN-beta levels than wild-type controls
• at 18 h after i.v. VSV infection (2 106 pfu per g body weight), mice show significantly lower serum IL-6 levels than wild-type controls
• at 24 h after intranasal injection with influenza virus strain A/Puerto Rico/1981 H1N1 (PR8), mice show significantly lower serum IL-6 levels than wild-type controls

hematopoietic system
• isolated peritoneal macrophages show a marked reduction in VSV-dependent induction of phosphorylated IRF3 (p-IRF3), consistent with a reduced antiviral innate response to RNA viruses





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory