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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Syngr3em1Pave
endonuclease-mediated mutation 1, Patrik Verstreken
MGI:6690242
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Syngr3em1Pave/Syngr3em1Pave C57BL/6-Syngr3em1Pave MGI:6690264
cx2
Syngr3em1Pave/Syngr3+
Tg(Prnp-MAPT*P301S)PS19Vle/0
involves: C3H * C57BL/6 MGI:6690265


Genotype
MGI:6690264
hm1
Allelic
Composition
Syngr3em1Pave/Syngr3em1Pave
Genetic
Background
C57BL/6-Syngr3em1Pave
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Syngr3em1Pave mutation (0 available); any Syngr3 mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• normal motor behavior

embryo
N
• born at expected Mendelian ratio

growth/size/body
N
• normal body weight, no gross abnormalities

mortality/aging
N
• viable, normal lifespan

reproductive system




Genotype
MGI:6690265
cx2
Allelic
Composition
Syngr3em1Pave/Syngr3+
Tg(Prnp-MAPT*P301S)PS19Vle/0
Genetic
Background
involves: C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Syngr3em1Pave mutation (0 available); any Syngr3 mutation (17 available)
Tg(Prnp-MAPT*P301S)PS19Vle mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• normal working memory as evidenced by performance in Morris water maze test at age 6-7 months

hematopoietic system
• increased number of activated microglia in stratum lucidum

immune system
• increased number of activated microglia in stratum lucidum

nervous system
N
• normal long-term potentiation response to three-theta-burst-stimulation (TBS) in mossy fiber CA3 synapses at age 6-7 months
• normal long-term potentiation response in Schaffer collateral CA1 synapses at age 8 months
• no loss of synapses in synaptic stratum lucidum area at age 8-9 months
• normal number of mossy fiber boutons at age 8-9 months
• increased number of activated microglia in stratum lucidum
• increased number of reactive astrocytes in stratum lucidum





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory