Phenotypes associated with this allele

• Allele Symbol: Fitm2^tm1Nani
• Allele Name: targeted mutation 1, Natsumi Nishihama
• Allele ID: MGI:6690473
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fitm2^tm1Nani/Fitm2^tm1Nani	Not Specified	MGI:6690502
ht2	Fitm2^tm1Nani/Fitm2^+	Not Specified	MGI:6690503

Genotype
MGI:6690502

hm1

• Allelic Composition: Fitm2^tm1Nani/Fitm2^tm1Nani
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:303195 )

• embryos die around E9-10

Genotype
MGI:6690503

ht2

• Allelic Composition: Fitm2^tm1Nani/Fitm2⁺
• Genetic Background: Not Specified

cardiovascular system

cardiovascular system phenotype ( J:303195 )

N • normal ejection fraction at age 22 months

N • normal left ventricular weight at age 24 months

N • normal left ventricle expansion and ejection fraction reduction up to 8 weeks after trans-aortic constriction (TAC)

decreased heart left ventricle size ( J:303195 )

• shorter left ventricular end-diastolic dimension (LVDd) and left ventricular end-systolic dimension (LVDs) at age 22 months

decreased heart right ventricle weight ( J:303195 )

• at age 24 months

growth/size/body

growth/size/body region phenotype ( J:303195 )

N • normal body weight at age 22 and 24 months

mortality/aging

mortality/aging ( J:303195 )

N • viable and normal lifespan

decreased susceptibility to induced morbidity/mortality ( J:303195 )

• attenuated heart left ventricle expansion, right heart ventricle weight increase and ejection fraction reduction after trans-aortic constriction (TAC)

• increased survival after TAC

• no body weight reduction 8 weeks after TAC

respiratory system

respiratory system phenotype ( J:303195 )

N • normal lung weight increase after trans-aortic constriction (TAC)