Analysis Tools
immune system
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• mice have slightly fewer CD4 single positive T cells in the thymus
• however, no major changes are observed in T cell development or function
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• mice have slightly fewer CD8 single positive T cells in the thymus and lymph nodes
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hematopoietic system
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• mice have slightly fewer CD4 single positive T cells in the thymus
• however, no major changes are observed in T cell development or function
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• mice have slightly fewer CD8 single positive T cells in the thymus and lymph nodes
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homeostasis/metabolism
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• Western blot analysis revealed that the upper band of the TMC8 protein doublet is absent in thymocytes, unlike in wild-type cells; however, no Tmc8 mRNA reduction is observed
• a decrease in CIB1 (calcium and integrin binding 1) protein level is observed in thymocytes and lymph node cells, with no apparent Cib1 mRNA reduction in thymocytes
• a small CIB1 protein reduction is seen in primary keratinocytes
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growth/size/body
| N |
• homozygotes are viable and grow normally with no apparent abnormalities up to 18 months of age
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reproductive system
| N |
• mice breed normally
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integument
| N |
• no gross abnormalities or histological changes are observed in skin
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