Phenotypes associated with this allele

• Allele Symbol: Tmc8^tm1.1Les
• Allele Name: targeted mutation 1.1, Lawrence E Samelson
• Allele ID: MGI:6690849
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tmc8^tm1.1Les/Tmc8^tm1.1Les	B6.129S6(Cg)-Tmc8^tm1.1Les	MGI:6694019

Genotype
MGI:6694019

hm1

• Allelic Composition: Tmc8^tm1.1Les/Tmc8^tm1.1Les
• Genetic Background: B6.129S6(Cg)-Tmc8^tm1.1Les

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased CD4-positive, alpha-beta T cell number ( J:300461 )

• mice have slightly fewer CD4 single positive T cells in the thymus

• however, no major changes are observed in T cell development or function

decreased CD8-positive, alpha-beta T cell number ( J:300461 )

• mice have slightly fewer CD8 single positive T cells in the thymus and lymph nodes

hematopoietic system

decreased CD4-positive, alpha-beta T cell number ( J:300461 )

• mice have slightly fewer CD4 single positive T cells in the thymus

• however, no major changes are observed in T cell development or function

decreased CD8-positive, alpha-beta T cell number ( J:300461 )

• mice have slightly fewer CD8 single positive T cells in the thymus and lymph nodes

homeostasis/metabolism

abnormal protein level ( J:300461 )

• thymocyte lysates show a decrease in the level and molecular size of TMC6 protein, but no Tmc6 mRNA reduction, relative to wild-type cells

• a decrease in CIB1 (calcium and integrin binding 1) protein level is observed in thymocytes and lymph node cells, with no apparent Cib1 mRNA reduction in thymocytes

growth/size/body

growth/size/body region phenotype ( J:300461 )

N • homozygotes are viable and grow normally with no apparent abnormalities up to 18 months of age

reproductive system

reproductive system phenotype ( J:300461 )

N • mice breed normally

integument

integument phenotype ( J:300461 )

N • no gross abnormalities or histological changes are observed in skin