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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dock11tm1.1Mmar
targeted mutation 1.1, Mitsuo Maruyama
MGI:6690850
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Dock11tm1.1Mmar/Dock11tm1.1Mmar Not Specified MGI:6690856


Genotype
MGI:6690856
hm1
Allelic
Composition		 Dock11tm1.1Mmar/Dock11tm1.1Mmar
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dock11tm1.1Mmar mutation (0 available); any Dock11 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal thymus cell ratio ( J:238172 )
• increased thymic CD4+ T cell percentage

immune system
immune system phenotype ( J:238172 )
N
• normal number of viable B and T cells in bone marrow, spleen, thymus and peritoneal cavi
• normal spleen and thymus histology
• normal immune responses against NP-CGG, TNP-LPS and TNP-Ficoll
• normal marginal metallophilic macrophage (MMM) and marginal zone macrophage (MZM) numbers in spleen
• normal LPS-induced spleen marginal zone B cell proliferation
• normal migration of spleen marginal zone B cells towards B lymphocyte chemoattractant (BLC) and SDF-1alpha
abnormal thymus cell ratio ( J:238172 )
• increased thymic CD4+ T cell percentage
abnormal metallophilic macrophage morphology ( J:238172 )
• sparse MMM ring around spleen marginal zone
abnormal spleen marginal zone morphology ( J:238172 )
• narrowing of B cell region (B220+ region outside CD169+ MZ macrophages)
decreased marginal zone B cell number ( J:238172 )
• reduction of percentage of B cells in spleen

hematopoietic system
abnormal thymus cell ratio ( J:238172 )
• increased thymic CD4+ T cell percentage
abnormal metallophilic macrophage morphology ( J:238172 )
• sparse MMM ring around spleen marginal zone
abnormal spleen marginal zone morphology ( J:238172 )
• narrowing of B cell region (B220+ region outside CD169+ MZ macrophages)
decreased marginal zone B cell number ( J:238172 )
• reduction of percentage of B cells in spleen

growth/size/body
growth/size/body region phenotype ( J:238172 )
N
• no gross abnormalities

mortality/aging
mortality/aging ( J:238172 )
N
• viable

reproductive system




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory