Phenotypes associated with this allele

• Allele Symbol: Trim8^em1Holi
• Allele Name: endonuclease-mediated mutation 1, Hongliang Li
• Allele ID: MGI:6690866
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trim8^em1Holi/Trim8^em1Holi	involves: C57BL/6J	MGI:6693527

Genotype
MGI:6693527

hm1

• Allelic Composition: Trim8^em1Holi/Trim8^em1Holi
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:303651 )

N • no gross abnormalities in cardiac morphology or function

growth/size/body

growth/size/body region phenotype ( J:303651 )

N • healthy, without gross abnormalities

mortality/aging

mortality/aging ( J:303651 )

N • viable

decreased susceptibility to induced morbidity/mortality ( J:303068 , J:303651 )

• significantly reduced alanine aminotransferase (ALT), serum aspartate aminotransferase (AST) and alkaline phosphatase (ALP) serum levels 6 and 24 h. after reperfusion following hepatic ischemia (J:303068)

• significantly smaller necrotic areas in liver after hepatic ischemia/reperfusion (I/R) (J:303068)

• significantly reduced CD11B+, LY6G+ and F4/80+ cell infiltration in liver 6 h. after reperfusion following hepatic ischemia (J:303068)

• significantly reduced TNFA and CCL2 serum levels 24 h. after reperfusion following hepatic ischemia (J:303068)

• significantly reduced apoptosis in liver after hepatic ischemia/reperfusion (I/R) (J:303068)

• reduced cardiac hypertrophy and reduced increase in heart weight to body weight (HW/BW) and tibia length (HW/TL) and lung weight to body weight (LW/BW) ratios and cardiomyocyte cross-sectional area 4 weeks after aortic banding (J:303651)

• reduced extent of cardiac interstitial and perivascular fibrosis 4 weeks after aortic banding (J:303651)

• less cardiac ventricular dilation (reduced left ventricle end-systolic and end-diastolic dimension) and lower decrease of fractional shortening 4 weeks after aortic banding (J:303651)

reproductive system

reproductive system phenotype ( J:303651 )

N • fertile