Phenotypes associated with this allele

• Allele Symbol: Tmem74^em1Fehan
• Allele Name: endonuclease-mediated mutation 1, Feng Han
• Allele ID: MGI:6690870
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tmem74^em1Fehan/Tmem74^em1Fehan	C57BL/6-Tmem74^em1Fehan	MGI:6690894

Genotype
MGI:6690894

hm1

• Allelic Composition: Tmem74^em1Fehan/Tmem74^em1Fehan
• Genetic Background: C57BL/6-Tmem74^em1Fehan

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:302698 )

N • normal behavior in rotarod, traction and pole tests

N • normal cognitive behavior

N • normal speed in light-dark test in males

increased anxiety-related response ( J:302698 )

• fewer open arm entries in elevated zero-maze (EZM) test

• fewer center square entries and less time spent there in open field test (OFT)

• fewer light compartment entries and less time spent there in light-dark test in males

• longer latency to feed in novelty-suppressed feeding (NSF) test in males

decreased locomotor activity ( J:302698 )

• fewer center square entries and less time spent there in open field test (OFT)

• fewer open arm entries in elevated zero-maze (EZM) test

nervous system

nervous system phenotype ( J:302698 )

♂N • normal Na+ and K+ currents in basolateral amygdaloid nucleus (BLA) and medial prefrontal cortex (mPFC) neurons

♂N • normal medium after-hyperpolarization (mAHP) potential in basolateral amygdaloid nucleus (BLA) and medial prefrontal cortex (mPFC) neurons

abnormal nervous system electrophysiology ( J:302698 )

• lower current density of hyperpolarization-activated cyclic nucleotidegated (HCN) channels in BLA pyramidal neurons

• slower activation kinetics in BLA pyramidal neurons

• normal membrane capacitance in basolateral amygdaloid nucleus (BLA) pyramidal neurons

• higher input resistance and membrane time constant in basolateral amygdaloid nucleus (BLA) pyramidal neurons in males

• BLA pyramidal neurons are more sensitive to depolarizing current injections and are more excitable in males

• smaller voltage drop in response to hyperpolarizing current injection in BLA pyramidal neurons in males

• lower hyperpolarizing current amplitude in BLA pyramidal neurons in males

growth/size/body

growth/size/body region phenotype ( J:302698 )

N • normal body and organ weights