Phenotypes associated with this allele

• Allele Symbol: Col1a1^{tm1(tetO-GFP,-RNAi:Eef1a1)Mcg}
• Allele Name: targeted mutation 1, McGill University
• Allele ID: MGI:6693286
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Col1a1^tm1(tetO-GFP,-RNAi:Eef1a1)Mcg/Col1a1^+ Sst^tm2.1(cre)Zjh/Sst^+	involves: 129S4/SvJae * C57BL/6J	MGI:6693445
cn2	Col1a1^tm1(tetO-GFP,-RNAi:Eef1a1)Mcg/Col1a1^+ Tg(Prkcd-glc-1/CFP,-cre)EH124Gsat/0	involves: C57BL/6J * FVB/NTac	MGI:6693444

Genotype
MGI:6693445

cn1

• Allelic Composition: Col1a1^{tm1(tetO-GFP,-RNAi:Eef1a1)Mcg}/Col1a1⁺; Sst^{tm2.1(cre)Zjh}/Sst⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:297390 )

N • mice virally expressing a cre-dependent tet transactivator exhibit normal behavior in an open field and exploration of an elevated plus maze

impaired cued conditioning behavior ( J:297390 )

• mice virally expressing a cre-dependent tet transactivator exhibit reduced long term memory in a cued threat-conditioning paradigm compared with wild-type

• however, supplementation with doxycycline rescues phenotype

Genotype
MGI:6693444

cn2

• Allelic Composition: Col1a1^{tm1(tetO-GFP,-RNAi:Eef1a1)Mcg}/Col1a1⁺; Tg(Prkcd-glc-1/CFP,-cre)EH124Gsat/0
• Genetic Background: involves: C57BL/6J * FVB/NTac

behavior/neurological

abnormal cued conditioning behavior ( J:297390 )

• mice virally expressing a cre-dependent tet transactivator exhibit impaired conditioned safety response to withdrawal of cued stimuli compared with wild-type mice

• however, acquisition of differential threat associative memory is normal

decreased anxiety-related response ( J:297390 )

• increased exploration of an elevated plus maze in mice virally expressing a cre-dependent tet transactivator