About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Eef1a1tm1Klan
targeted mutation 1, Eric Klann
MGI:6693287
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Eef1a1tm1Klan/Eef1a1tm1Klan
Ssttm2.1(cre)Zjh/Sst+
involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J MGI:6693446
cn2
Eef1a1tm1Klan/Eef1a1tm1Klan
Tg(Prkcd-glc-1/CFP,-cre)EH124Gsat/0
involves: 129S6/SvEvTac * C57BL/6J * FVB/NTac MGI:6693448


Genotype
MGI:6693446
cn1
Allelic
Composition
Eef1a1tm1Klan/Eef1a1tm1Klan
Ssttm2.1(cre)Zjh/Sst+
Genetic
Background
involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eef1a1tm1Klan mutation (1 available); any Eef1a1 mutation (60 available)
Ssttm2.1(cre)Zjh mutation (4 available); any Sst mutation (35 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice infusion with asunaprivir (drug inducer of iPKR) exhibit reduced memory in a cued threat-conditioning paradigm compared with wild-type




Genotype
MGI:6693448
cn2
Allelic
Composition
Eef1a1tm1Klan/Eef1a1tm1Klan
Tg(Prkcd-glc-1/CFP,-cre)EH124Gsat/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6J * FVB/NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eef1a1tm1Klan mutation (1 available); any Eef1a1 mutation (60 available)
Tg(Prkcd-glc-1/CFP,-cre)EH124Gsat mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice infusion with asunaprivir (drug inducer of iPKR) exhibit impaired conditioned safety response to withdrawal of cued stimuli compared with wild-type mice
• however, acquisition of differential threat associative memory is normal





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
07/05/2024
MGI 6.24
The Jackson Laboratory