reproductive system
N |
• male mice are fertile
|
• reduced nuclear envelop stiffness
|
• increasing with maternal age
|
• female mice are infertile or subfertile
|
• female mice are infertile or subfertile
|
hematopoietic system
endocrine/exocrine glands
cellular
• reduced nuclear envelop stiffness
|
• increasing with maternal age
|
• zygotes from null oocytes fertilized with wild-type sperm fail to develop beyond the 8 cell stage
|