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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Nemp1em1Hmc
endonuclease-mediated mutation 1, Helen McNeill
MGI:6693344
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Nemp1em1Hmc/Nemp1em1Hmc C57BL/6N-Nemp1em1Hmc MGI:6693346


Genotype
MGI:6693346
hm1
Allelic
Composition
Nemp1em1Hmc/Nemp1em1Hmc
Genetic
Background
C57BL/6N-Nemp1em1Hmc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nemp1em1Hmc mutation (0 available); any Nemp1 mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
N
• male mice are fertile
• reduced nuclear envelop stiffness
• increasing with maternal age
• female mice are infertile or subfertile
• female mice are infertile or subfertile

hematopoietic system

endocrine/exocrine glands

cellular
• reduced nuclear envelop stiffness
• increasing with maternal age
• zygotes from null oocytes fertilized with wild-type sperm fail to develop beyond the 8 cell stage





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory