Phenotypes associated with this allele

• Allele Symbol: Actl9^em1Glin
• Allele Name: endonuclease-mediated mutation 1, Ge Lin
• Allele ID: MGI:6693352
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Actl9^em1Glin/Actl9^em1Glin	involves: C57BL/6J	MGI:6693353

Genotype
MGI:6693353

hm1

• Allelic Composition: Actl9^em1Glin/Actl9^em1Glin
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal acrosome morphology ( J:303517 )

♂ • ruffled acrosome

abnormal acrosome assembly ( J:303517 )

♂ • mice exhibit defects in acrosomal biogenesis, showing proacrosomal vesicles in the Golgi phase that remain atypical and separated

abnormal proacrosomal vesicle fusion ( J:303517 )

♂ • proacrosomal vesicles fail to fuse into an entire vesicle in the cap phase

detached acrosome ( J:303517 )

♂ • sperm exhibit a loosened perinuclear theca structure where the acrosome is detached from the nuclear envelope

abnormal spermatid morphology ( J:303517 )

♂ • spermatids exhibit defects in the fusion of proacrosomal vesicles that result in ruffled acrosomes with a loosened perinuclear theca formed in mature sperm

impaired fertilization ( J:303517 )

♂ • mutant sperm fail to fertilize wild-type oocytes following intracytoplasmic sperm injection

♂ • however, testicular size, testis-to-body weight ratio, sperm concentration, sperm viability and sperm motility are normal in males and testis and epididymis show that components in the seminiferous epithelium and sperm number in the caudal epididymis are normal

cellular

abnormal acrosome morphology ( J:303517 )

♂ • ruffled acrosome

abnormal acrosome assembly ( J:303517 )

♂ • mice exhibit defects in acrosomal biogenesis, showing proacrosomal vesicles in the Golgi phase that remain atypical and separated

abnormal proacrosomal vesicle fusion ( J:303517 )

♂ • proacrosomal vesicles fail to fuse into an entire vesicle in the cap phase

detached acrosome ( J:303517 )

♂ • sperm exhibit a loosened perinuclear theca structure where the acrosome is detached from the nuclear envelope

abnormal spermatid morphology ( J:303517 )

♂ • spermatids exhibit defects in the fusion of proacrosomal vesicles that result in ruffled acrosomes with a loosened perinuclear theca formed in mature sperm