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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Laynem1Romd
endonuclease-mediated mutation 1, Michael D Rosenblum
MGI:6693354
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Laynem1Romd/Laynem1Romd
Tg(Cd8a-cre,-GFP)1Yzo/0 		involves: C57BL/6 MGI:6693356


Genotype
MGI:6693356
cn1
Allelic
Composition		 Laynem1Romd/Laynem1Romd
Tg(Cd8a-cre,-GFP)1Yzo/0
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Laynem1Romd mutation (0 available); any Layn mutation (22 available)
Tg(Cd8a-cre,-GFP)1Yzo mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:302853 )
N
• display normal frequencies of CD8+ cells across multiple organs
abnormal CD8-positive, alpha-beta T cell physiology ( J:302853 )
• when transplanted into Rag2 null hosts that are then transplanted with MC38 adenocarcinoma cells there is a marked reduction in the accumulation of cells first in the tumor and then in secondary lymphoid organs

neoplasm
increased tumor growth/size ( J:302853 )
• enhanced growth of tumors developing from transplanted B16-F10 melanoma or MC38 adenocarcinoma cells

hematopoietic system
abnormal CD8-positive, alpha-beta T cell physiology ( J:302853 )
• when transplanted into Rag2 null hosts that are then transplanted with MC38 adenocarcinoma cells there is a marked reduction in the accumulation of cells first in the tumor and then in secondary lymphoid organs




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory