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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Aicdatm1(cre)Uba
targeted mutation 1, Uttiya Basu
MGI:6693484
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ightm1Mnz/Ightm1Mnz
Dis3tm1.1Uba/Dis3tm1.1Uba
Aicdatm1(cre)Uba/Aicda+ 		involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 MGI:6695985


Genotype
MGI:6695985
cn1
Allelic
Composition		 Ightm1Mnz/Ightm1Mnz
Dis3tm1.1Uba/Dis3tm1.1Uba
Aicdatm1(cre)Uba/Aicda+
Genetic
Background		 involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aicdatm1(cre)Uba mutation (0 available); any Aicda mutation (57 available)
Dis3tm1.1Uba mutation (0 available); any Dis3 mutation (43 available)
Ightm1Mnz mutation (4 available); any Igh mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal somatic hypermutation frequency ( J:302856 )
• mice immunized to induced somatic hypermutation show higher mutation frequencies in germinal center derived B cells
• the C to T mutation frequency is increased and inversely, the G to A mutation frequency is decreased in germinal cell B cells, indicating dysregulation of activation-induced cytidine deaminase activity at the V(D)J exon during somatic hypermutation

hematopoietic system
abnormal somatic hypermutation frequency ( J:302856 )
• mice immunized to induced somatic hypermutation show higher mutation frequencies in germinal center derived B cells
• the C to T mutation frequency is increased and inversely, the G to A mutation frequency is decreased in germinal cell B cells, indicating dysregulation of activation-induced cytidine deaminase activity at the V(D)J exon during somatic hypermutation




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory