All Phenotypes Dis3<tm1.1Uba> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Dis3^tm1.1Uba
targeted mutation 1.1, Uttiya Basu
MGI:6693492

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Igh^tm1Mnz/Igh^tm1Mnz Dis3^tm1.1Uba/Dis3^tm1.1Uba Aicda^tm1(cre)Uba/Aicda⁺	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6	MGI:6695985
cn2	Dis3^tm1.1Uba/Dis3^tm1.1Uba Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte}/Gt(ROSA)26Sor⁺	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac	MGI:6695984

Allelic Composition	Igh^tm1Mnz/Igh^tm1Mnz Dis3^tm1.1Uba/Dis3^tm1.1Uba Aicda^tm1(cre)Uba/Aicda⁺
Genetic Background	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aicda^tm1(cre)Uba mutation (0 available); any Aicda mutation (57 available)
Dis3^tm1.1Uba mutation (0 available); any Dis3 mutation (43 available)
Igh^tm1Mnz mutation (4 available); any Igh mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal somatic hypermutation frequency ( J:302856 )

• mice immunized to induced somatic hypermutation show higher mutation frequencies in germinal center derived B cells

• the C to T mutation frequency is increased and inversely, the G to A mutation frequency is decreased in germinal cell B cells, indicating dysregulation of activation-induced cytidine deaminase activity at the V(D)J exon during somatic hypermutation

hematopoietic system

abnormal somatic hypermutation frequency ( J:302856 )

• mice immunized to induced somatic hypermutation show higher mutation frequencies in germinal center derived B cells

Allelic Composition	Dis3^tm1.1Uba/Dis3^tm1.1Uba Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte}/Gt(ROSA)26Sor⁺
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dis3^tm1.1Uba mutation (0 available); any Dis3 mutation (43 available)
Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte} mutation (2 available); any Gt(ROSA)26Sor mutation (993 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal B cell morphology ( J:302856 )

• B cells exhibit altered chromosome architecture genome wide in tamoxifen-treated mice

abnormal class switch recombination ( J:302856 )

• B cells in vitro stimulated with tamoxifen exhibit a defect in class-switch recombination

• tamoxifen-treated B cells show a reduction to class-switch recombination to IgG1

• tamoxifen-treated mice show an increase in microhomology-mediated DNA junctions in B cells