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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(CAG-cat,-Trim8)4Holi
transgene insertion 4, Hongliang Li
MGI:6693494
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Tg(CAG-cat,-Trim8)4Holi/0
involves: C57BL/6J * FVB/N MGI:6693528


Genotype
MGI:6693528
cn1
Allelic
Composition
A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Tg(CAG-cat,-Trim8)4Holi/0
Genetic
Background
involves: C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A1cfTg(Myh6-cre/Esr1*)1Jmk mutation (5 available); any A1cf mutation (39 available)
Tg(CAG-cat,-Trim8)4Holi mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• no gross abnormalities in cardiac morphology or function

growth/size/body
• healthy, without gross abnormalities

mortality/aging
• viable
• increased cardiac hypertrophy and greater increase in heart weight to body weight (HW/BW) and tibia length (HW/TL) and lung weight to body weight (LW/BW) ratios and cardiomyocyte cross-sectional area 4 weeks after aortic banding
• increased extent of cardiac interstitial and perivascular fibrosis 4 weeks after aortic banding
• more cardiac ventricular dilation (increased left ventricle end-systolic and end-diastolic dimension) and greater decrease of fractional shortening 4 weeks after aortic banding

reproductive system





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory