Analysis Tools
immune system
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• mice exhibit increased susceptibility to DSS-induced colitis, with mice showing an accelerated decrease in weight and a greater weight loss, higher DAI, more severe colon shortening, more mucosal erosion, crypt destruction, goblet cell loss and inflammatory cell infiltration in the colon
• however, no differences from wild-type mice are seen in spontaneous colitis
• mice treated with DSS and supplemented with A. muciniphila show less weight loss, have longer colon, lower DAI scores, more epithelial stability and less inflammatory cell infiltration that DSS treated mice
• mice treated with DSS and ciprofloxacin (to inhibit bacilli) show reduced weight loss, longer colon length, and lower clinical and histological colitis scores
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• mice with DSS-induced colitis exhibit a greater enlargement of the spleen than wild-type mice
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• mice with DSS-induced colitis exhibit more white blood cells than wild-type mice
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• mice show increased mRNA expression of IL-1beta, IL-6 and TNF-alpha at the recovery stage of DSS-induced colitis
(J:285283)
• mice fed a high-fat diet show higher mRNA levels of inflammatory cytokines TNF-alpha and IL-6 than in wild-type mice
(J:302658)
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• mice show increased macrophage infiltration in the liver compared to wild-type mice on a high-fat diet
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adipose tissue
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• mice fed a high-fat diet exhibit a greater increase in epididymal white adipose tissue weight than wild-type mice
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digestive/alimentary system
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• bacilli are over-represented and A. muciniphila are under-represented in the fecal microflora of mutant mice
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• mice exhibit increased susceptibility to DSS-induced colitis, with mice showing an accelerated decrease in weight and a greater weight loss, higher DAI, more severe colon shortening, more mucosal erosion, crypt destruction, goblet cell loss and inflammatory cell infiltration in the colon
• however, no differences from wild-type mice are seen in spontaneous colitis
• mice treated with DSS and supplemented with A. muciniphila show less weight loss, have longer colon, lower DAI scores, more epithelial stability and less inflammatory cell infiltration that DSS treated mice
• mice treated with DSS and ciprofloxacin (to inhibit bacilli) show reduced weight loss, longer colon length, and lower clinical and histological colitis scores
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liver/biliary system
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• mice fed a high-fat diet exhibit a greater increase in liver weight than wild-type mice
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• hepatic total cholesterol levels are increased compared to wild-type mice on a high-fat diet
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• hepatic triglyceride levels are increased compared to wild-type mice on a high-fat diet
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• mice show increased macrophage infiltration in the liver compared to wild-type mice on a high-fat diet
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• mice develop greater fatty liver within 4 months on a high-fat diet compared to wild-type mice
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growth/size/body
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• mice fed a high-fat diet gain more weight than wild-type mice despite consuming a similar amount of food
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• mice fed a high-fat diet exhibit a greater increase in liver weight than wild-type mice
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• mice with DSS-induced colitis exhibit a greater enlargement of the spleen than wild-type mice
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hematopoietic system
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• mice with DSS-induced colitis exhibit a greater enlargement of the spleen than wild-type mice
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• mice with DSS-induced colitis exhibit more white blood cells than wild-type mice
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homeostasis/metabolism
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• mice fed a high-fat diet gain more weight than wild-type mice despite consuming a similar amount of food
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• mice fed a high-fat diet show a decreased in plasma total cholesterol levels compared to wild-type mice
• however, plasma triglyceride and high-density lipoprotein cholesterol remain unchanged compared to wild-type mice on a high-fat diet
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• mice fed a high-fat diet show a decrease in low-density lipoprotein cholesterol levels compared to wild-type mice
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• mice fed a high-fat diet exhibit a greater increase in plasma alanine aminotransferase levels than wild-type mice
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• mice fed a high-fat diet exhibit a greater increase in plasma aspartate aminotransferase levels than wild-type mice
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• hepatic total cholesterol levels are increased compared to wild-type mice on a high-fat diet
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• hepatic triglyceride levels are increased compared to wild-type mice on a high-fat diet
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• mice show increased mRNA expression of IL-1beta, IL-6 and TNF-alpha at the recovery stage of DSS-induced colitis
(J:285283)
• mice fed a high-fat diet show higher mRNA levels of inflammatory cytokines TNF-alpha and IL-6 than in wild-type mice
(J:302658)
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• mice injected with azoxymethane followed by DSS to induce colitis-associated colorectal cancer show much more and larger tumors that develop in the middle and distal part of the colons than wild-type colons
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neoplasm
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• mice injected with azoxymethane followed by DSS to induce colitis-associated colorectal cancer show much more and larger tumors that develop in the middle and distal part of the colons than wild-type colons
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