Phenotypes associated with this allele

• Allele Symbol: Fndc5^em21Gpt
• Allele Name: endonuclease-mediated mutation 21, GemPharmatech Co., Ltd
• Allele ID: MGI:6693646
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fndc5^em21Gpt/Fndc5^em21Gpt	C57BL/6JGpt-Fndc5^em21Cd/Gpt	MGI:6693651

Genotype
MGI:6693651

hm1

• Allelic Composition: Fndc5^em21Gpt/Fndc5^em21Gpt
• Genetic Background: C57BL/6JGpt-Fndc5^em21Cd/Gpt

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal behavior ( J:247171 )

• normal food intake when fed high-fat diet (HFD)

growth/size/body

growth/size/body region phenotype ( J:247171 )

N • normal body weight when fed high-fat diet (HFD)

increased susceptibility to diet-induced obesity ( J:247171 , J:291193 )

• increased susceptibility to steatosis after when fed high-fat diet (HFD): increased liver weight and liver weight-to-body weight ratio (J:247171)

• larger increase in serum NEFA, TG and cholesterol levels when fed HFD (J:247171)

• larger increase in serum alanine aminotransferase (ALT) and serum aspartate aminotransferase (AST) when fed HFD (J:247171)

cellular

impaired autophagy ( J:247171 )

• reduced autophagy after fasting

abnormal fatty acid oxidation ( J:247171 )

• lower increase in fatty acid oxidation after fasting

homeostasis/metabolism

impaired autophagy ( J:247171 )

• reduced autophagy after fasting

abnormal fatty acid oxidation ( J:247171 )

• lower increase in fatty acid oxidation after fasting

increased susceptibility to diet-induced obesity ( J:247171 , J:291193 )

• increased susceptibility to steatosis after when fed high-fat diet (HFD): increased liver weight and liver weight-to-body weight ratio (J:247171)

• larger increase in serum NEFA, TG and cholesterol levels when fed HFD (J:247171)

• larger increase in serum alanine aminotransferase (ALT) and serum aspartate aminotransferase (AST) when fed HFD (J:247171)

abnormal circulating lipid level ( J:247171 )

• larger increase in serum nonestesterified fatty acid (NEFA) and triglyceride (TG) levels after fasting

• larger increase in serum NEFA, TG and cholesterol levels when fed HFD

abnormal circulating enzyme level ( J:247171 )

• larger increase in serum alanine aminotransferase (ALT) and serum aspartate aminotransferase (AST) when fed HFD

liver/biliary system

increased susceptibility to hepatic steatosis ( J:247171 )

• increased lipid accumulation in liver after fasting, becoming severe after 16h fasting

increased susceptibility to diet-induced hepatic steatosis ( J:247171 )

• increased susceptibility to steatosis after when fed high-fat diet (HFD): increased liver weight and liver weight-to-body weight ratio

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:291193 )

• increased heart left ventricular hypertrophy when fed high-fat diet (HFD): greater increase in IVSd (interventricular septum at diastole), LVPWd (left ventricular posterior wall at diastole) and cardiomyocyte diameter

• increased cardiac oxidative stress and inflammation when fed high-fat diet (HFD)