All Phenotypes Ces5a<em1Zuk> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ces5a^em1Zuk
endonuclease-mediated mutation 1, Martin M Matzuk
MGI:6693654

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ces5a^em1Zuk/Ces5a^em1Zuk	involves: C57BL/6 * DBA/2	MGI:6693754

Allelic Composition	Ces5a^em1Zuk/Ces5a^em1Zuk
Genetic Background	involves: C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ces5a^em1Zuk mutation (0 available); any Ces5a mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:295177 )

N	• mice exhibit normal testis histology and sperm morphology

oligozoospermia ( J:295177 )

• with decreased average path velocity and progressive velocity after hyperactivation

asthenozoospermia ( J:295177 )

abnormal epididymis morphology ( J:295177 )

• dilated lumen, inflammation, and abnormal epithelia

reduced male fertility ( J:295177 )

• male mice sire fewer litters and pups

• however, litter size is normal over 3 month mating period

cellular

oligozoospermia ( J:295177 )

• with decreased average path velocity and progressive velocity after hyperactivation

asthenozoospermia ( J:295177 )

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