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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Impg1em1Visu
endonuclease-mediated mutation 1, Visvanathan Ramamurthy
MGI:6693683
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Impg1em1Visu/Impg1em1Visu involves: C57BL/6J * DBA/2 MGI:6693690
cx2
 		Impg1em1Visu/Impg1em1Visu
Impg2em1Visu/Impg2em1Visu 		involves: C57BL/6J * DBA/2 MGI:6693691


Genotype
MGI:6693690
hm1
Allelic
Composition		 Impg1em1Visu/Impg1em1Visu
Genetic
Background		 involves: C57BL/6J * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Impg1em1Visu mutation (0 available); any Impg1 mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
vision/eye phenotype ( J:288311 )
N
• no changes in scotopic or photopic ERG responses at 8 months of age
abnormal photoreceptor outer segment morphology ( J:288311 )
• the cone specific marker PNA disappears around the outer segments but remains around the inner segments

nervous system
abnormal photoreceptor outer segment morphology ( J:288311 )
• the cone specific marker PNA disappears around the outer segments but remains around the inner segments




Genotype
MGI:6693691
cx2
Allelic
Composition		 Impg1em1Visu/Impg1em1Visu
Impg2em1Visu/Impg2em1Visu
Genetic
Background		 involves: C57BL/6J * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Impg1em1Visu mutation (0 available); any Impg1 mutation (48 available)
Impg2em1Visu mutation (0 available); any Impg2 mutation (69 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
vision/eye phenotype ( J:288311 )
N
• no changes in scotopic or photopic ERG responses or sub-retinal lesions at 8 months of age unlike in mice homozygous for Impg2 allele alone

immune system
microgliosis ( J:288311 )
• microglial activation is reduced but not eliminated compared to mice homozygous for Impg2 allele alone

nervous system
microgliosis ( J:288311 )
• microglial activation is reduced but not eliminated compared to mice homozygous for Impg2 allele alone

hematopoietic system
microgliosis ( J:288311 )
• microglial activation is reduced but not eliminated compared to mice homozygous for Impg2 allele alone




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory