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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Del(8Ddx19a-Ddx19b)1Chaw
deletion, Chr 8, Changjiang Weng 1
MGI:6693696
Summary 2 genotypes


Genotype
MGI:6693796
hm1
Allelic
Composition		 Del(8Ddx19a-Ddx19b)1Chaw/Del(8Ddx19a-Ddx19b)1Chaw
Genetic
Background		 C57BL/6-Del(8Ddx19a-Ddx19b)1Chaw
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:6693797
ht2
Allelic
Composition		 Del(8Ddx19a-Ddx19b)1Chaw/+
Genetic
Background		 C57BL/6-Del(8Ddx19a-Ddx19b)1Chaw
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased interferon-alpha secretion ( J:289833 )
• by macrophages incubated with poly(I:C) or infected with Sendai virus (SeV)
increased interferon-beta secretion ( J:289833 )
• by macrophages incubated with poly(I:C) or infected with Sendai virus (SeV)
decreased susceptibility to Picornaviridae infection ( J:289833 )
• fewer copies of virus genome in mouse embryo fibroblasts (MEFs) infected with Encephalomyocarditis virus (EMCV)
decreased susceptibility to Picornaviridae infection induced morbidity/mortality ( J:289833 )
• significantly less pronounced damage to brain and heart after Encephalomyocarditis virus (EMCV) infection
• lower viral load in brain and heart after Encephalomyocarditis virus (EMCV) infection

growth/size/body
growth/size/body region phenotype ( J:289833 )
N
• no gross abnormalities

mortality/aging
mortality/aging ( J:289833 )
N
• viable
decreased susceptibility to Picornaviridae infection induced morbidity/mortality ( J:289833 )
• significantly less pronounced damage to brain and heart after Encephalomyocarditis virus (EMCV) infection
• lower viral load in brain and heart after Encephalomyocarditis virus (EMCV) infection

reproductive system




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory